Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival.
<h4>Background</h4>The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).<h4>Methods</h4>All patients diagnosed with and treated for CUP between January 1, 2000, an...
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oai:doaj.org-article:2f73b8f90e2b43228b279e6e33a632492021-11-25T05:54:43ZHuman papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival.1932-620310.1371/journal.pone.0110456https://doaj.org/article/2f73b8f90e2b43228b279e6e33a632492014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110456https://doaj.org/toc/1932-6203<h4>Background</h4>The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).<h4>Methods</h4>All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.<h4>Results</h4>Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.<h4>Conclusion</h4>A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.David Hebbelstrup JensenNora HedbackLena SpechtEstrid HøgdallElo AndersenMarianne Hamilton TherkildsenLennart Friis-HansenBodil NorrildChristian von BuchwaldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e110456 (2014) |
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Medicine R Science Q David Hebbelstrup Jensen Nora Hedback Lena Specht Estrid Høgdall Elo Andersen Marianne Hamilton Therkildsen Lennart Friis-Hansen Bodil Norrild Christian von Buchwald Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| description |
<h4>Background</h4>The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).<h4>Methods</h4>All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.<h4>Results</h4>Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.<h4>Conclusion</h4>A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up. |
| format |
article |
| author |
David Hebbelstrup Jensen Nora Hedback Lena Specht Estrid Høgdall Elo Andersen Marianne Hamilton Therkildsen Lennart Friis-Hansen Bodil Norrild Christian von Buchwald |
| author_facet |
David Hebbelstrup Jensen Nora Hedback Lena Specht Estrid Høgdall Elo Andersen Marianne Hamilton Therkildsen Lennart Friis-Hansen Bodil Norrild Christian von Buchwald |
| author_sort |
David Hebbelstrup Jensen |
| title |
Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| title_short |
Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| title_full |
Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| title_fullStr |
Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| title_full_unstemmed |
Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| title_sort |
human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/2f73b8f90e2b43228b279e6e33a63249 |
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