Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis

DICER is involved in the processing of miRNAs, where the RNase IIIa and IIIb domains are thought to cut the 3p and 5p hairpin arms, respectively. Here, in endometrial cancer, the authors identify an RNase IIIa mutation, which phenocopies mutations in the RNase IIIb domain.

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Autores principales:	Jeffrey Vedanayagam, Walid K. Chatila, Bülent Arman Aksoy, Sonali Majumdar, Anders Jacobsen Skanderup, Emek Demir, Nikolaus Schultz, Chris Sander, Eric C. Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f755b2a10804cc9b94ebb7187c03ce0
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spelling	oai:doaj.org-article:2f755b2a10804cc9b94ebb7187c03ce02021-12-02T16:57:46ZCancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis10.1038/s41467-019-11610-12041-1723https://doaj.org/article/2f755b2a10804cc9b94ebb7187c03ce02019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11610-1https://doaj.org/toc/2041-1723DICER is involved in the processing of miRNAs, where the RNase IIIa and IIIb domains are thought to cut the 3p and 5p hairpin arms, respectively. Here, in endometrial cancer, the authors identify an RNase IIIa mutation, which phenocopies mutations in the RNase IIIb domain.Jeffrey VedanayagamWalid K. ChatilaBülent Arman AksoySonali MajumdarAnders Jacobsen SkanderupEmek DemirNikolaus SchultzChris SanderEric C. LaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey Vedanayagam Walid K. Chatila Bülent Arman Aksoy Sonali Majumdar Anders Jacobsen Skanderup Emek Demir Nikolaus Schultz Chris Sander Eric C. Lai Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
description	DICER is involved in the processing of miRNAs, where the RNase IIIa and IIIb domains are thought to cut the 3p and 5p hairpin arms, respectively. Here, in endometrial cancer, the authors identify an RNase IIIa mutation, which phenocopies mutations in the RNase IIIb domain.
format	article
author	Jeffrey Vedanayagam Walid K. Chatila Bülent Arman Aksoy Sonali Majumdar Anders Jacobsen Skanderup Emek Demir Nikolaus Schultz Chris Sander Eric C. Lai
author_facet	Jeffrey Vedanayagam Walid K. Chatila Bülent Arman Aksoy Sonali Majumdar Anders Jacobsen Skanderup Emek Demir Nikolaus Schultz Chris Sander Eric C. Lai
author_sort	Jeffrey Vedanayagam
title	Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
title_short	Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
title_full	Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
title_fullStr	Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
title_full_unstemmed	Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
title_sort	cancer-associated mutations in dicer1 rnase iiia and iiib domains exert similar effects on mirna biogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2f755b2a10804cc9b94ebb7187c03ce0
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Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis

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