Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.

<h4>Objectives</h4>The aim of this study was to evaluate the discriminant capability of the patient acceptable symptom state (PASS) according to disease activity, in a cohort of Italian patients affected by systemic Lupus erythematosus (SLE).<h4>Methods</h4>Consecutive SLE pa...

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Autores principales:	Fabrizio Conti, Fulvia Ceccarelli, Laura Massaro, Viviana A Pacucci, Francesca Miranda, Simona Truglia, Enrica Cipriano, Francesco Martinelli, Ilaria Leccese, Francesca Romana Spinelli, Cristiano Alessandri, Carlo Perricone, Guido Valesini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f76570f46e7467cbd1e3f40006fde2f
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spelling	oai:doaj.org-article:2f76570f46e7467cbd1e3f40006fde2f2021-11-18T08:56:17ZEvaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.1932-620310.1371/journal.pone.0073517https://doaj.org/article/2f76570f46e7467cbd1e3f40006fde2f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039971/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>The aim of this study was to evaluate the discriminant capability of the patient acceptable symptom state (PASS) according to disease activity, in a cohort of Italian patients affected by systemic Lupus erythematosus (SLE).<h4>Methods</h4>Consecutive SLE patients were enrolled. At each visit, the patients underwent a complete physical examination and the clinical/laboratory data were collected in a standardized, computerized, and electronically-filled form. The evaluation of serum complement C3 and C4 levels and determination of autoantibodies was obtained. Disease activity was assessed with the SLEDAI-2K and ECLAM, while chronic damage was measured with the SLICC. Finally, PASS was assessed in all patients by asking to answer yes or no to a single question.<h4>Results</h4>One hundred sixty-five patients were enrolled (M/F 12/153; mean age 40.4±11.8 years, mean disease duration 109.1±96.2 months). No patients refused to answer, suggesting the acceptability of PASS. A total of 80% of patients rated their state as acceptable. The patients with an acceptable status had significantly lower mean SLEDAI-2K and ECLAM scores than the others [1.8±2.7 versus 3.4±2.3(P=0.004); 0.7±0.9 versus 1.4±1.1(P=0.0027)]. No significant differences were observed when considering chronic damage, evaluated with SLICC.<h4>Conclusions</h4>In the clinical practice, SLE patients assessment performed by using complex disease activity indices such as SLEDAI-2K and ECLAM, could be time consuming. In our study, for the first time, we used PASS, a quick and easily comprehensible tool, to evaluate the patients' status, this single question seems to be able to discriminate patients with different disease activity, especially when this is determined by musculoskeletal involvement.Fabrizio ContiFulvia CeccarelliLaura MassaroViviana A PacucciFrancesca MirandaSimona TrugliaEnrica CiprianoFrancesco MartinelliIlaria LecceseFrancesca Romana SpinelliCristiano AlessandriCarlo PerriconeGuido ValesiniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73517 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabrizio Conti Fulvia Ceccarelli Laura Massaro Viviana A Pacucci Francesca Miranda Simona Truglia Enrica Cipriano Francesco Martinelli Ilaria Leccese Francesca Romana Spinelli Cristiano Alessandri Carlo Perricone Guido Valesini Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
description	<h4>Objectives</h4>The aim of this study was to evaluate the discriminant capability of the patient acceptable symptom state (PASS) according to disease activity, in a cohort of Italian patients affected by systemic Lupus erythematosus (SLE).<h4>Methods</h4>Consecutive SLE patients were enrolled. At each visit, the patients underwent a complete physical examination and the clinical/laboratory data were collected in a standardized, computerized, and electronically-filled form. The evaluation of serum complement C3 and C4 levels and determination of autoantibodies was obtained. Disease activity was assessed with the SLEDAI-2K and ECLAM, while chronic damage was measured with the SLICC. Finally, PASS was assessed in all patients by asking to answer yes or no to a single question.<h4>Results</h4>One hundred sixty-five patients were enrolled (M/F 12/153; mean age 40.4±11.8 years, mean disease duration 109.1±96.2 months). No patients refused to answer, suggesting the acceptability of PASS. A total of 80% of patients rated their state as acceptable. The patients with an acceptable status had significantly lower mean SLEDAI-2K and ECLAM scores than the others [1.8±2.7 versus 3.4±2.3(P=0.004); 0.7±0.9 versus 1.4±1.1(P=0.0027)]. No significant differences were observed when considering chronic damage, evaluated with SLICC.<h4>Conclusions</h4>In the clinical practice, SLE patients assessment performed by using complex disease activity indices such as SLEDAI-2K and ECLAM, could be time consuming. In our study, for the first time, we used PASS, a quick and easily comprehensible tool, to evaluate the patients' status, this single question seems to be able to discriminate patients with different disease activity, especially when this is determined by musculoskeletal involvement.
format	article
author	Fabrizio Conti Fulvia Ceccarelli Laura Massaro Viviana A Pacucci Francesca Miranda Simona Truglia Enrica Cipriano Francesco Martinelli Ilaria Leccese Francesca Romana Spinelli Cristiano Alessandri Carlo Perricone Guido Valesini
author_facet	Fabrizio Conti Fulvia Ceccarelli Laura Massaro Viviana A Pacucci Francesca Miranda Simona Truglia Enrica Cipriano Francesco Martinelli Ilaria Leccese Francesca Romana Spinelli Cristiano Alessandri Carlo Perricone Guido Valesini
author_sort	Fabrizio Conti
title	Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
title_short	Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
title_full	Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
title_fullStr	Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
title_full_unstemmed	Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.
title_sort	evaluation of the patient acceptable symptom state (pass) in italian patients affected by systemic lupus erythematosus: association with disease activity indices.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2f76570f46e7467cbd1e3f40006fde2f
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Evaluation of the patient acceptable symptom state (PASS) in Italian patients affected by systemic lupus erythematosus: association with disease activity indices.

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