The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized. J147 is a modified version of curcumin with superior bioavailability and stability. However, there is no report about the effects of J147 on pigmentation...

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Autores principales:	Jinpeng Lv, Ying Yang, Bingyi Jia, Siqi Li, Ximei Zhang, Rongyin Gao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	J147 hypopigmentary effects melanosome transport ERK pathway MITF degradation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2f76fbbd70724c6d820568bf3df0ff4f
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spelling	oai:doaj.org-article:2f76fbbd70724c6d820568bf3df0ff4f2021-11-30T12:17:06ZThe Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation1663-981210.3389/fphar.2021.783730https://doaj.org/article/2f76fbbd70724c6d820568bf3df0ff4f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.783730/fullhttps://doaj.org/toc/1663-9812The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized. J147 is a modified version of curcumin with superior bioavailability and stability. However, there is no report about the effects of J147 on pigmentation in vitro and in vivo. In our studies, we investigated the hypopigmentary effects of J147 treatment on melanocytes and explored the underlying mechanism. The present studies suggested that J147 suppressed both basal and α-MSH-induced melanogenesis, as well as decreased melanocyte dendricity extension and melanosome transport. J147 played these roles mainly by activating the extracellular signal-regulated protein kinase (ERK) pathway. Once activated, it resulted in MITF degradation and further down-regulated the expression of tyrosinase, TRP-1, TRP-2, Myosin Va, Rab27a and Cdc42, ultimately inhibited melanin synthesis and melanosome transport. Furthermore, the hypopigmentary effects of J147 were demonstrated in vivo in a zebrafish model and UVB-induced hyperpigmentation model in brown guinea pigs. Our findings also suggested that J147 exhibited no cytotoxicity in vitro and in vivo. Taken together, these data confirmed that J147 may prove quite useful as a safer natural skin-whitening agent.Jinpeng LvJinpeng LvYing YangBingyi JiaSiqi LiXimei ZhangRongyin GaoFrontiers Media S.A.articleJ147hypopigmentary effectsmelanosome transportERK pathwayMITF degradationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	J147 hypopigmentary effects melanosome transport ERK pathway MITF degradation Therapeutics. Pharmacology RM1-950
spellingShingle	J147 hypopigmentary effects melanosome transport ERK pathway MITF degradation Therapeutics. Pharmacology RM1-950 Jinpeng Lv Jinpeng Lv Ying Yang Bingyi Jia Siqi Li Ximei Zhang Rongyin Gao The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
description	The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized. J147 is a modified version of curcumin with superior bioavailability and stability. However, there is no report about the effects of J147 on pigmentation in vitro and in vivo. In our studies, we investigated the hypopigmentary effects of J147 treatment on melanocytes and explored the underlying mechanism. The present studies suggested that J147 suppressed both basal and α-MSH-induced melanogenesis, as well as decreased melanocyte dendricity extension and melanosome transport. J147 played these roles mainly by activating the extracellular signal-regulated protein kinase (ERK) pathway. Once activated, it resulted in MITF degradation and further down-regulated the expression of tyrosinase, TRP-1, TRP-2, Myosin Va, Rab27a and Cdc42, ultimately inhibited melanin synthesis and melanosome transport. Furthermore, the hypopigmentary effects of J147 were demonstrated in vivo in a zebrafish model and UVB-induced hyperpigmentation model in brown guinea pigs. Our findings also suggested that J147 exhibited no cytotoxicity in vitro and in vivo. Taken together, these data confirmed that J147 may prove quite useful as a safer natural skin-whitening agent.
format	article
author	Jinpeng Lv Jinpeng Lv Ying Yang Bingyi Jia Siqi Li Ximei Zhang Rongyin Gao
author_facet	Jinpeng Lv Jinpeng Lv Ying Yang Bingyi Jia Siqi Li Ximei Zhang Rongyin Gao
author_sort	Jinpeng Lv
title	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
title_short	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
title_full	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
title_fullStr	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
title_full_unstemmed	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
title_sort	inhibitory effect of curcumin derivative j147 on melanogenesis and melanosome transport by facilitating erk-mediated mitf degradation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2f76fbbd70724c6d820568bf3df0ff4f
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The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

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