Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine.

Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine.

We report a new subgroup of Type III Restriction-Modification systems that use m4C methylation for host protection. Recognition specificities for six such systems, each recognizing a novel motif, have been determined using single molecule real-time DNA sequencing. In contrast to all previously chara...

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Autores principales: Iain A Murray, Yvette A Luyten, Alexey Fomenkov, Nan Dai, Ivan R Corrêa, William G Farmerie, Tyson A Clark, Jonas Korlach, Richard D Morgan, Richard J Roberts
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/2f77b6fdc04f4e65b94bfac091b7ee0f
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