Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity

Abstract Acupuncture has been widely used as a therapeutic intervention, and the brain network plays a crucial role in its neural mechanism. This study aimed to investigate the acupuncture mechanism from peripheral to central by identifying how the peripheral molecular signals induced by acupuncture...

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Autores principales:	Ji-Yeun Park, Seong-Jin Cho, Soon-Ho Lee, Yeonhee Ryu, Jae-Hwan Jang, Seung-Nam Kim, Hi-Joon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f850178f1b44fccb13ad2cdc1caf27b
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spelling	oai:doaj.org-article:2f850178f1b44fccb13ad2cdc1caf27b2021-12-02T15:54:09ZPeripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity10.1038/s41598-021-84273-y2045-2322https://doaj.org/article/2f850178f1b44fccb13ad2cdc1caf27b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84273-yhttps://doaj.org/toc/2045-2322Abstract Acupuncture has been widely used as a therapeutic intervention, and the brain network plays a crucial role in its neural mechanism. This study aimed to investigate the acupuncture mechanism from peripheral to central by identifying how the peripheral molecular signals induced by acupuncture affect the brain neural responses and its functional connectivity. We confirmed that peripheral ERK activation by acupuncture plays a role in initiating acupuncture-induced peripheral proteomic changes in mice. The brain neural activities in the neocortex, hippocampus, thalamus, hypothalamus, periaqueductal grey, and nucleus of the solitary tract (Sol) were significantly changed after acupuncture, and these were altered by peripheral MEK/MAPK inhibition. The arcuate nucleus and lateral hypothalamus were the most affected by acupuncture and peripheral MEK/MAPK inhibition. The hypothalamic area was the most contributing brain region in contrast task PLS analysis. Acupuncture provoked extensive changes in brain functional connectivity, and the posterior hypothalamus showed the highest betweenness centrality after acupuncture. After brain hub identification, the Sol and cingulate cortex were selected as hub regions that reflect both degree and betweenness centrality after acupuncture. These results suggest that acupuncture activates brain functional connectivity and that peripheral ERK induced by acupuncture plays a role in initiating brain neural activation and its functional connectivity.Ji-Yeun ParkSeong-Jin ChoSoon-Ho LeeYeonhee RyuJae-Hwan JangSeung-Nam KimHi-Joon ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji-Yeun Park Seong-Jin Cho Soon-Ho Lee Yeonhee Ryu Jae-Hwan Jang Seung-Nam Kim Hi-Joon Park Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
description	Abstract Acupuncture has been widely used as a therapeutic intervention, and the brain network plays a crucial role in its neural mechanism. This study aimed to investigate the acupuncture mechanism from peripheral to central by identifying how the peripheral molecular signals induced by acupuncture affect the brain neural responses and its functional connectivity. We confirmed that peripheral ERK activation by acupuncture plays a role in initiating acupuncture-induced peripheral proteomic changes in mice. The brain neural activities in the neocortex, hippocampus, thalamus, hypothalamus, periaqueductal grey, and nucleus of the solitary tract (Sol) were significantly changed after acupuncture, and these were altered by peripheral MEK/MAPK inhibition. The arcuate nucleus and lateral hypothalamus were the most affected by acupuncture and peripheral MEK/MAPK inhibition. The hypothalamic area was the most contributing brain region in contrast task PLS analysis. Acupuncture provoked extensive changes in brain functional connectivity, and the posterior hypothalamus showed the highest betweenness centrality after acupuncture. After brain hub identification, the Sol and cingulate cortex were selected as hub regions that reflect both degree and betweenness centrality after acupuncture. These results suggest that acupuncture activates brain functional connectivity and that peripheral ERK induced by acupuncture plays a role in initiating brain neural activation and its functional connectivity.
format	article
author	Ji-Yeun Park Seong-Jin Cho Soon-Ho Lee Yeonhee Ryu Jae-Hwan Jang Seung-Nam Kim Hi-Joon Park
author_facet	Ji-Yeun Park Seong-Jin Cho Soon-Ho Lee Yeonhee Ryu Jae-Hwan Jang Seung-Nam Kim Hi-Joon Park
author_sort	Ji-Yeun Park
title	Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
title_short	Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
title_full	Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
title_fullStr	Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
title_full_unstemmed	Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity
title_sort	peripheral erk modulates acupuncture-induced brain neural activity and its functional connectivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f850178f1b44fccb13ad2cdc1caf27b
work_keys_str_mv	AT jiyeunpark peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT seongjincho peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT soonholee peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT yeonheeryu peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT jaehwanjang peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT seungnamkim peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity AT hijoonpark peripheralerkmodulatesacupunctureinducedbrainneuralactivityanditsfunctionalconnectivity
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Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity

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