Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents

Abstract We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or str...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Frederik Jan Moorhouse, Sonia Cornell, Lucia Gerstl, Moritz Tacke, Timo Roser, Florian Heinen, Michaela Bonfert, Celina von Stülpnagel, Matias Wagner, Ingo Borggraefe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f8b29cfd20d4088b9ac55f0ac6eef3f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f8b29cfd20d4088b9ac55f0ac6eef3f
record_format	dspace
spelling	oai:doaj.org-article:2f8b29cfd20d4088b9ac55f0ac6eef3f2021-12-02T12:33:06ZCognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents10.1038/s41598-020-78218-02045-2322https://doaj.org/article/2f8b29cfd20d4088b9ac55f0ac6eef3f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78218-0https://doaj.org/toc/2045-2322Abstract We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or structural/numeric chromosomal etiology (genetic epilepsies, GE group). Cognitive (total IQ and subcategories) and behavioral parameters (CBCL) were assessed at the tertiary epilepsy center of the University of Munich (Germany). We used ANOVA with post-hoc Bonferroni-correction to explore significant mean differences and Fisher’s exact test for significant proportional differences of intelligence impairment and behavioral problems. 126 (56 IGE/GGE, 26 IFE, 44 GE) patients were available. Total IQ was 89.0 ± 15.9 (95% CI 84.5–93.4) for IGE/GGE, 94.8 ± 18.1 (95% CI 87.3–102.3) for IFE and 76.4 ± 22.4 (95% CI 67.6–85.3) for GE (p = 0.001). The same trend was significant for all but one IQ subcategory. The rate of patients with an intelligence impairment (total IQ < 70) was higher for GE (40%) than for IGE/GGE (14%) and for IFE (7%) patients (p = 0.033). There were no significant differences between groups for behavior scores and behavioral problems. This study shows that the current ILAE classification of epilepsies with genetic etiology creates a heterogeneous group of patients with respect to cognitive performance but not behavior. These findings may help in further delineating epilepsies as regards cognitive performance, notwithstanding their closely related etiological classification.Frederik Jan MoorhouseSonia CornellLucia GerstlMoritz TackeTimo RoserFlorian HeinenMichaela BonfertCelina von StülpnagelMatias WagnerIngo BorggraefeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frederik Jan Moorhouse Sonia Cornell Lucia Gerstl Moritz Tacke Timo Roser Florian Heinen Michaela Bonfert Celina von Stülpnagel Matias Wagner Ingo Borggraefe Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
description	Abstract We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or structural/numeric chromosomal etiology (genetic epilepsies, GE group). Cognitive (total IQ and subcategories) and behavioral parameters (CBCL) were assessed at the tertiary epilepsy center of the University of Munich (Germany). We used ANOVA with post-hoc Bonferroni-correction to explore significant mean differences and Fisher’s exact test for significant proportional differences of intelligence impairment and behavioral problems. 126 (56 IGE/GGE, 26 IFE, 44 GE) patients were available. Total IQ was 89.0 ± 15.9 (95% CI 84.5–93.4) for IGE/GGE, 94.8 ± 18.1 (95% CI 87.3–102.3) for IFE and 76.4 ± 22.4 (95% CI 67.6–85.3) for GE (p = 0.001). The same trend was significant for all but one IQ subcategory. The rate of patients with an intelligence impairment (total IQ < 70) was higher for GE (40%) than for IGE/GGE (14%) and for IFE (7%) patients (p = 0.033). There were no significant differences between groups for behavior scores and behavioral problems. This study shows that the current ILAE classification of epilepsies with genetic etiology creates a heterogeneous group of patients with respect to cognitive performance but not behavior. These findings may help in further delineating epilepsies as regards cognitive performance, notwithstanding their closely related etiological classification.
format	article
author	Frederik Jan Moorhouse Sonia Cornell Lucia Gerstl Moritz Tacke Timo Roser Florian Heinen Michaela Bonfert Celina von Stülpnagel Matias Wagner Ingo Borggraefe
author_facet	Frederik Jan Moorhouse Sonia Cornell Lucia Gerstl Moritz Tacke Timo Roser Florian Heinen Michaela Bonfert Celina von Stülpnagel Matias Wagner Ingo Borggraefe
author_sort	Frederik Jan Moorhouse
title	Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_short	Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_full	Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_fullStr	Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_full_unstemmed	Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_sort	cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2f8b29cfd20d4088b9ac55f0ac6eef3f
work_keys_str_mv	AT frederikjanmoorhouse cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT soniacornell cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT luciagerstl cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT moritztacke cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT timoroser cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT florianheinen cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT michaelabonfert cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT celinavonstulpnagel cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT matiaswagner cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents AT ingoborggraefe cognitiveperformanceandbehavioracrossidiopathicgeneticepilepsiesinchildrenandadolescents
_version_	1718393850006863872

Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents

Ejemplares similares