IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to h...

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Autores principales: Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerrière-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stéphanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce
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Sumario:Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to help repress chronic skin inflammation.

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