IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to h...

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Autores principales:	Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerrière-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stéphanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove, Nicolas Poirier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce
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spelling	oai:doaj.org-article:2f8d89dcfb614001945d31eee5d1a5ce2021-12-02T14:39:44ZIL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates10.1038/s41467-018-06804-y2041-1723https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06804-yhttps://doaj.org/toc/2041-1723Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to help repress chronic skin inflammation.Lyssia BelarifCaroline MaryLola JacquemontHoa Le MaiRichard DangerJeremy HervouetDavid MinaultVirginie ThepenierVeronique Nerrière-DaguinElisabeth NguyenSabrina PengamEric LargyArnaud DelobelBernard MartinetStéphanie Le Bas-BernardetSophie BrouardJean-Paul SoulillouNicolas DegauqueGilles BlanchoBernard VanhoveNicolas PoirierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lyssia Belarif Caroline Mary Lola Jacquemont Hoa Le Mai Richard Danger Jeremy Hervouet David Minault Virginie Thepenier Veronique Nerrière-Daguin Elisabeth Nguyen Sabrina Pengam Eric Largy Arnaud Delobel Bernard Martinet Stéphanie Le Bas-Bernardet Sophie Brouard Jean-Paul Soulillou Nicolas Degauque Gilles Blancho Bernard Vanhove Nicolas Poirier IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
description	Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to help repress chronic skin inflammation.
format	article
author	Lyssia Belarif Caroline Mary Lola Jacquemont Hoa Le Mai Richard Danger Jeremy Hervouet David Minault Virginie Thepenier Veronique Nerrière-Daguin Elisabeth Nguyen Sabrina Pengam Eric Largy Arnaud Delobel Bernard Martinet Stéphanie Le Bas-Bernardet Sophie Brouard Jean-Paul Soulillou Nicolas Degauque Gilles Blancho Bernard Vanhove Nicolas Poirier
author_facet	Lyssia Belarif Caroline Mary Lola Jacquemont Hoa Le Mai Richard Danger Jeremy Hervouet David Minault Virginie Thepenier Veronique Nerrière-Daguin Elisabeth Nguyen Sabrina Pengam Eric Largy Arnaud Delobel Bernard Martinet Stéphanie Le Bas-Bernardet Sophie Brouard Jean-Paul Soulillou Nicolas Degauque Gilles Blancho Bernard Vanhove Nicolas Poirier
author_sort	Lyssia Belarif
title	IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
title_short	IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
title_full	IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
title_fullStr	IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
title_full_unstemmed	IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
title_sort	il-7 receptor blockade blunts antigen-specific memory t cell responses and chronic inflammation in primates
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2f8d89dcfb614001945d31eee5d1a5ce
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IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

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