Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)

Abstract Amphibian habitats are easily contaminated by several pollutants, and in agricultural landscapes the likely exposure scenario is represented by pesticides. Many of these substances are known or suspected to act as endocrine disrupting chemicals (EDCs). The goal of the present study was to a...

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Autores principales:	Ilaria Bernabò, Antonello Guardia, Rachele Macirella, Sandro Tripepi, Elvira Brunelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f90209807e945369465283413f08e13
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spelling	oai:doaj.org-article:2f90209807e945369465283413f08e132021-12-02T15:05:50ZChronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)10.1038/s41598-017-07367-62045-2322https://doaj.org/article/2f90209807e945369465283413f08e132017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07367-6https://doaj.org/toc/2045-2322Abstract Amphibian habitats are easily contaminated by several pollutants, and in agricultural landscapes the likely exposure scenario is represented by pesticides. Many of these substances are known or suspected to act as endocrine disrupting chemicals (EDCs). The goal of the present study was to assess the effects of pyrimethanil, a common-used but also overlooked fungicide, on liver, kidney and gonadal differentiation of Hyla intermedia. Through a multi-organ evaluation, we demonstrated that a long term exposure to two environmentally relevant concentrations of pyrimethanil (5 and 50 µg/L) elicits a range of toxic responses. First we showed that pyrimethanil induces underdevelopment of ovaries and interferes with normal sexual differentiation, thus revealing the endocrine disruption potential of this fungicide. Moreover we revealed that all considered organs are seriously affected by this fungicide and both necrosis and apoptosis contribute to the histological response. This is the first report on the effects of pyrimethanil on gonads, liver and kidney histology of a non-model species and it demonstrates that the hazardous properties of this fungicide can result from several pathological processes affecting different key compartments of amphibian.Ilaria BernabòAntonello GuardiaRachele MacirellaSandro TripepiElvira BrunelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilaria Bernabò Antonello Guardia Rachele Macirella Sandro Tripepi Elvira Brunelli Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
description	Abstract Amphibian habitats are easily contaminated by several pollutants, and in agricultural landscapes the likely exposure scenario is represented by pesticides. Many of these substances are known or suspected to act as endocrine disrupting chemicals (EDCs). The goal of the present study was to assess the effects of pyrimethanil, a common-used but also overlooked fungicide, on liver, kidney and gonadal differentiation of Hyla intermedia. Through a multi-organ evaluation, we demonstrated that a long term exposure to two environmentally relevant concentrations of pyrimethanil (5 and 50 µg/L) elicits a range of toxic responses. First we showed that pyrimethanil induces underdevelopment of ovaries and interferes with normal sexual differentiation, thus revealing the endocrine disruption potential of this fungicide. Moreover we revealed that all considered organs are seriously affected by this fungicide and both necrosis and apoptosis contribute to the histological response. This is the first report on the effects of pyrimethanil on gonads, liver and kidney histology of a non-model species and it demonstrates that the hazardous properties of this fungicide can result from several pathological processes affecting different key compartments of amphibian.
format	article
author	Ilaria Bernabò Antonello Guardia Rachele Macirella Sandro Tripepi Elvira Brunelli
author_facet	Ilaria Bernabò Antonello Guardia Rachele Macirella Sandro Tripepi Elvira Brunelli
author_sort	Ilaria Bernabò
title	Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
title_short	Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
title_full	Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
title_fullStr	Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
title_full_unstemmed	Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)
title_sort	chronic exposures to fungicide pyrimethanil: multi-organ effects on italian tree frog (hyla intermedia)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f90209807e945369465283413f08e13
work_keys_str_mv	AT ilariabernabo chronicexposurestofungicidepyrimethanilmultiorganeffectsonitaliantreefroghylaintermedia AT antonelloguardia chronicexposurestofungicidepyrimethanilmultiorganeffectsonitaliantreefroghylaintermedia AT rachelemacirella chronicexposurestofungicidepyrimethanilmultiorganeffectsonitaliantreefroghylaintermedia AT sandrotripepi chronicexposurestofungicidepyrimethanilmultiorganeffectsonitaliantreefroghylaintermedia AT elvirabrunelli chronicexposurestofungicidepyrimethanilmultiorganeffectsonitaliantreefroghylaintermedia
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Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia)

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