Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Ying Hu,1,2 Hai Bo Tan,1 Xin Mei Wang,3 Hua Rong,1 Hong Ping Cui,1 Hao Cui2 Departments of Ophthalmology, 1Shanghai East Hospital of Tongji University, Shanghai, 2First Affiliated Hospital, 3Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China Abstract:...

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Autores principales:	Hu Y, Tan HB, Wang XM, Rong H, Cui HP, Cui H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	glaucoma stem cell transplantation cell therapy ageing Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2f905fa9124c4dfa961dcfd9a6180ded
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spelling	oai:doaj.org-article:2f905fa9124c4dfa961dcfd9a6180ded2021-12-02T02:44:46ZBone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma1178-1998https://doaj.org/article/2f905fa9124c4dfa961dcfd9a6180ded2013-10-01T00:00:00Zhttps://www.dovepress.com/bone-marrow-mesenchymal-stem-cells-protect-against-retinal-ganglion-ce-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ying Hu,1,2 Hai Bo Tan,1 Xin Mei Wang,3 Hua Rong,1 Hong Ping Cui,1 Hao Cui2 Departments of Ophthalmology, 1Shanghai East Hospital of Tongji University, Shanghai, 2First Affiliated Hospital, 3Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China Abstract: Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma. Keywords: glaucoma, stem cell, transplantation, cell therapy, agingHu YTan HBWang XMRong HCui HPCui HDove Medical Pressarticleglaucomastem celltransplantationcell therapyageingGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1467-1470 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma stem cell transplantation cell therapy ageing Geriatrics RC952-954.6
spellingShingle	glaucoma stem cell transplantation cell therapy ageing Geriatrics RC952-954.6 Hu Y Tan HB Wang XM Rong H Cui HP Cui H Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
description	Ying Hu,1,2 Hai Bo Tan,1 Xin Mei Wang,3 Hua Rong,1 Hong Ping Cui,1 Hao Cui2 Departments of Ophthalmology, 1Shanghai East Hospital of Tongji University, Shanghai, 2First Affiliated Hospital, 3Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China Abstract: Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma. Keywords: glaucoma, stem cell, transplantation, cell therapy, aging
format	article
author	Hu Y Tan HB Wang XM Rong H Cui HP Cui H
author_facet	Hu Y Tan HB Wang XM Rong H Cui HP Cui H
author_sort	Hu Y
title	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_short	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_fullStr	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full_unstemmed	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_sort	bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2f905fa9124c4dfa961dcfd9a6180ded
work_keys_str_mv	AT huy bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma AT tanhb bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma AT wangxm bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma AT rongh bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma AT cuihp bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma AT cuih bonemarrowmesenchymalstemcellsprotectagainstretinalganglioncelllossinagedratswithglaucoma
_version_	1718402152675672064

Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

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