Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation

Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient and leads only to a partial opening of the riboso...

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Autores principales:	Vanessa de Jesus, Nusrat S. Qureshi, Sven Warhaut, Jasleen K. Bains, Marina S. Dietz, Mike Heilemann, Harald Schwalbe, Boris Fürtig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f9168db64244081a1ad083419291a8b
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spelling	oai:doaj.org-article:2f9168db64244081a1ad083419291a8b2021-12-02T17:06:34ZSwitching at the ribosome: riboswitches need rProteins as modulators to regulate translation10.1038/s41467-021-25024-52041-1723https://doaj.org/article/2f9168db64244081a1ad083419291a8b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25024-5https://doaj.org/toc/2041-1723Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient and leads only to a partial opening of the ribosome binding site and requires interaction with 30S-bound ribosomal protein S1, which acts as an RNA chaperone.Vanessa de JesusNusrat S. QureshiSven WarhautJasleen K. BainsMarina S. DietzMike HeilemannHarald SchwalbeBoris FürtigNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vanessa de Jesus Nusrat S. Qureshi Sven Warhaut Jasleen K. Bains Marina S. Dietz Mike Heilemann Harald Schwalbe Boris Fürtig Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
description	Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient and leads only to a partial opening of the ribosome binding site and requires interaction with 30S-bound ribosomal protein S1, which acts as an RNA chaperone.
format	article
author	Vanessa de Jesus Nusrat S. Qureshi Sven Warhaut Jasleen K. Bains Marina S. Dietz Mike Heilemann Harald Schwalbe Boris Fürtig
author_facet	Vanessa de Jesus Nusrat S. Qureshi Sven Warhaut Jasleen K. Bains Marina S. Dietz Mike Heilemann Harald Schwalbe Boris Fürtig
author_sort	Vanessa de Jesus
title	Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
title_short	Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
title_full	Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
title_fullStr	Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
title_full_unstemmed	Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
title_sort	switching at the ribosome: riboswitches need rproteins as modulators to regulate translation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f9168db64244081a1ad083419291a8b
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Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation

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