Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population

Abstract Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a...

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Autores principales:	Mohammed Dashti, Hussain Alsaleh, Juan L. Rodriguez-Flores, Muthukrishnan Eaaswarkhanth, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f949f6dc7d84ac88e698401c7084b55
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spelling	oai:doaj.org-article:2f949f6dc7d84ac88e698401c7084b552021-12-02T15:23:03ZMitochondrial haplogroup J associated with higher risk of obesity in the Qatari population10.1038/s41598-020-80040-72045-2322https://doaj.org/article/2f949f6dc7d84ac88e698401c7084b552021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80040-7https://doaj.org/toc/2045-2322Abstract Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a sister haplogroup of J is known to be associated with obesity in Caucasian subjects from Austria and Southern Italy. We aimed to delineate the mitochondrial haplogroups and variants associated with obesity in Qatari population. Mitochondrial genomes of 864 Qatari individuals were extracted from whole exome sequencing data with an average coverage of 77X. We distributed the participants into 2 sub-cohorts: obese (BMI ≥ 30) and non-obese (BMI < 30); the mean value of BMI from these two groups were 36.5 ± 5.7 and 26.5 ± 2.6, respectively. Mitochondrial haplogroup profiling followed by uni- and multivariant association tests adjusted for covariates were performed. Qatari individuals with mitochondrial haplogroup J had an increased (twofold) risk of obesity (odds ratio [OR] 1.925; 95% CI 1.234–3.002; P = 0.0038; the Bonferroni adjusted P value threshold is 0.0041), whereas the individuals with haplogroup X were at low risk of obesity (OR 0.387; 95% CI 0.175–0.857; P = 0.019). Further, a set of 38 mitochondrial variants were found to be associated (at P ≤ 0.05) with obesity in models adjusted for age, sex and haplogroup.Mohammed DashtiHussain AlsalehJuan L. Rodriguez-FloresMuthukrishnan EaaswarkhanthFahd Al-MullaThangavel Alphonse ThanarajNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammed Dashti Hussain Alsaleh Juan L. Rodriguez-Flores Muthukrishnan Eaaswarkhanth Fahd Al-Mulla Thangavel Alphonse Thanaraj Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
description	Abstract Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for example, X haplogroup is known to be associated with lower BMI and body fat mass in Northern Europeans and T haplogroup which is a sister haplogroup of J is known to be associated with obesity in Caucasian subjects from Austria and Southern Italy. We aimed to delineate the mitochondrial haplogroups and variants associated with obesity in Qatari population. Mitochondrial genomes of 864 Qatari individuals were extracted from whole exome sequencing data with an average coverage of 77X. We distributed the participants into 2 sub-cohorts: obese (BMI ≥ 30) and non-obese (BMI < 30); the mean value of BMI from these two groups were 36.5 ± 5.7 and 26.5 ± 2.6, respectively. Mitochondrial haplogroup profiling followed by uni- and multivariant association tests adjusted for covariates were performed. Qatari individuals with mitochondrial haplogroup J had an increased (twofold) risk of obesity (odds ratio [OR] 1.925; 95% CI 1.234–3.002; P = 0.0038; the Bonferroni adjusted P value threshold is 0.0041), whereas the individuals with haplogroup X were at low risk of obesity (OR 0.387; 95% CI 0.175–0.857; P = 0.019). Further, a set of 38 mitochondrial variants were found to be associated (at P ≤ 0.05) with obesity in models adjusted for age, sex and haplogroup.
format	article
author	Mohammed Dashti Hussain Alsaleh Juan L. Rodriguez-Flores Muthukrishnan Eaaswarkhanth Fahd Al-Mulla Thangavel Alphonse Thanaraj
author_facet	Mohammed Dashti Hussain Alsaleh Juan L. Rodriguez-Flores Muthukrishnan Eaaswarkhanth Fahd Al-Mulla Thangavel Alphonse Thanaraj
author_sort	Mohammed Dashti
title	Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
title_short	Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
title_full	Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
title_fullStr	Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
title_full_unstemmed	Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population
title_sort	mitochondrial haplogroup j associated with higher risk of obesity in the qatari population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f949f6dc7d84ac88e698401c7084b55
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Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population

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