Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status

Abstract Pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and neonatal health outcomes, with differences in risk observed between sexes. Given that the placenta is a sexually dimorphic organ and critical regulator of development, examining differences in placental mRNA and mi...

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Autores principales:	Jeliyah Clark, Lauren A. Eaves, Adriana R. Gaona, Hudson P. Santos, Lisa Smeester, Jacqueline T. Bangma, Julia E. Rager, T. Michael O’Shea, Rebecca C. Fry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f975be2e74248b0892ffbd9d88b0a2d
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spelling	oai:doaj.org-article:2f975be2e74248b0892ffbd9d88b0a2d2021-12-02T14:53:41ZPre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status10.1038/s41598-021-95051-12045-2322https://doaj.org/article/2f975be2e74248b0892ffbd9d88b0a2d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95051-1https://doaj.org/toc/2045-2322Abstract Pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and neonatal health outcomes, with differences in risk observed between sexes. Given that the placenta is a sexually dimorphic organ and critical regulator of development, examining differences in placental mRNA and miRNA expression in relation to pre-pregnancy BMI may provide insight into responses to maternal BMI in utero. Here, genome-wide mRNA and miRNA expression levels were assessed in the placentas of infants born extremely preterm. Differences in expression were evaluated according to pre-pregnancy BMI status (1) overall and (2) in male and female placentas separately. Overall, 719 mRNAs were differentially expressed in relation to underweight status. Unexpectedly, no genes were differentially expressed in relation to overweight or obese status. In male placentas, 572 mRNAs were associated with underweight status, with 503 (70%) overlapping genes identified overall. Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR-128-1-5p) associated with underweight status in male placentas. Pathways regulating placental nutrient metabolism and angiogenesis were among those enriched in mRNAs associated with underweight status in males. This study is among the first to highlight a sexually dimorphic response to low pre-pregnancy BMI in the placenta.Jeliyah ClarkLauren A. EavesAdriana R. GaonaHudson P. SantosLisa SmeesterJacqueline T. BangmaJulia E. RagerT. Michael O’SheaRebecca C. FryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeliyah Clark Lauren A. Eaves Adriana R. Gaona Hudson P. Santos Lisa Smeester Jacqueline T. Bangma Julia E. Rager T. Michael O’Shea Rebecca C. Fry Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
description	Abstract Pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and neonatal health outcomes, with differences in risk observed between sexes. Given that the placenta is a sexually dimorphic organ and critical regulator of development, examining differences in placental mRNA and miRNA expression in relation to pre-pregnancy BMI may provide insight into responses to maternal BMI in utero. Here, genome-wide mRNA and miRNA expression levels were assessed in the placentas of infants born extremely preterm. Differences in expression were evaluated according to pre-pregnancy BMI status (1) overall and (2) in male and female placentas separately. Overall, 719 mRNAs were differentially expressed in relation to underweight status. Unexpectedly, no genes were differentially expressed in relation to overweight or obese status. In male placentas, 572 mRNAs were associated with underweight status, with 503 (70%) overlapping genes identified overall. Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR-128-1-5p) associated with underweight status in male placentas. Pathways regulating placental nutrient metabolism and angiogenesis were among those enriched in mRNAs associated with underweight status in males. This study is among the first to highlight a sexually dimorphic response to low pre-pregnancy BMI in the placenta.
format	article
author	Jeliyah Clark Lauren A. Eaves Adriana R. Gaona Hudson P. Santos Lisa Smeester Jacqueline T. Bangma Julia E. Rager T. Michael O’Shea Rebecca C. Fry
author_facet	Jeliyah Clark Lauren A. Eaves Adriana R. Gaona Hudson P. Santos Lisa Smeester Jacqueline T. Bangma Julia E. Rager T. Michael O’Shea Rebecca C. Fry
author_sort	Jeliyah Clark
title	Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
title_short	Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
title_full	Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
title_fullStr	Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
title_full_unstemmed	Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
title_sort	pre-pregnancy bmi-associated mirna and mrna expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f975be2e74248b0892ffbd9d88b0a2d
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Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status

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