A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi

VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.

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Autores principales:	Corinne Stoetzel, Séverine Bär, Johan-Owen De Craene, Sophie Scheidecker, Christelle Etard, Johana Chicher, Jennifer R. Reck, Isabelle Perrault, Véronique Geoffroy, Kirsley Chennen, Uwe Strähle, Philippe Hammann, Sylvie Friant, Hélène Dollfus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f97f4e03fb6494dba321c86f0391b33
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spelling	oai:doaj.org-article:2f97f4e03fb6494dba321c86f0391b332021-12-02T17:32:08ZA mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi10.1038/ncomms135862041-1723https://doaj.org/article/2f97f4e03fb6494dba321c86f0391b332016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13586https://doaj.org/toc/2041-1723VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.Corinne StoetzelSéverine BärJohan-Owen De CraeneSophie ScheideckerChristelle EtardJohana ChicherJennifer R. ReckIsabelle PerraultVéronique GeoffroyKirsley ChennenUwe StrählePhilippe HammannSylvie FriantHélène DollfusNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corinne Stoetzel Séverine Bär Johan-Owen De Craene Sophie Scheidecker Christelle Etard Johana Chicher Jennifer R. Reck Isabelle Perrault Véronique Geoffroy Kirsley Chennen Uwe Strähle Philippe Hammann Sylvie Friant Hélène Dollfus A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
description	VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.
format	article
author	Corinne Stoetzel Séverine Bär Johan-Owen De Craene Sophie Scheidecker Christelle Etard Johana Chicher Jennifer R. Reck Isabelle Perrault Véronique Geoffroy Kirsley Chennen Uwe Strähle Philippe Hammann Sylvie Friant Hélène Dollfus
author_facet	Corinne Stoetzel Séverine Bär Johan-Owen De Craene Sophie Scheidecker Christelle Etard Johana Chicher Jennifer R. Reck Isabelle Perrault Véronique Geoffroy Kirsley Chennen Uwe Strähle Philippe Hammann Sylvie Friant Hélène Dollfus
author_sort	Corinne Stoetzel
title	A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
title_short	A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
title_full	A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
title_fullStr	A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
title_full_unstemmed	A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
title_sort	mutation in vps15 (pik3r4) causes a ciliopathy and affects ift20 release from the cis-golgi
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2f97f4e03fb6494dba321c86f0391b33
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A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi

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