Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle

In smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major anionic channel. Opening of these channels leads to chloride efflux and depolarization of the myocyte membrane. In this way, activation of the channels by a rise of intracellular [Ca2+], from a variety of sources,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susan Wray, Clodagh Prendergast, Sarah Arrowsmith
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	calcium-activated chloride channels vascular smooth muscle myometrial smooth muscle TMEM16A Anoctamin 1 excitability Physiology QP1-981
Acceso en línea:	https://doaj.org/article/2f988643e56549639d6acb4c8b3e7fa8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f988643e56549639d6acb4c8b3e7fa8
record_format	dspace
spelling	oai:doaj.org-article:2f988643e56549639d6acb4c8b3e7fa82021-11-16T18:40:32ZCalcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle1664-042X10.3389/fphys.2021.751008https://doaj.org/article/2f988643e56549639d6acb4c8b3e7fa82021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.751008/fullhttps://doaj.org/toc/1664-042XIn smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major anionic channel. Opening of these channels leads to chloride efflux and depolarization of the myocyte membrane. In this way, activation of the channels by a rise of intracellular [Ca2+], from a variety of sources, produces increased excitability and can initiate action potentials and contraction or increased tone. We now have a good mechanistic understanding of how the channels are activated and regulated, due to identification of TMEM16A (ANO1) as the molecular entity of the channel, but key questions remain. In reviewing these channels and comparing two distinct smooth muscles, myometrial and vascular, we expose the differences that occur in their activation mechanisms, properties, and control. We find that the myometrium only expresses “classical,” Ca2+-activated, and voltage sensitive channels, whereas both tonic and phasic blood vessels express classical, and non-classical, cGMP-regulated CaCC, which are voltage insensitive. This translates to more complex activation and regulation in vascular smooth muscles, irrespective of whether they are tonic or phasic. We therefore tentatively conclude that although these channels are expressed and functionally important in all smooth muscles, they are probably not part of the mechanisms governing phasic activity. Recent knockdown studies have produced unexpected functional results, e.g. no effects on labour and delivery, and tone increasing in some but decreasing in other vascular beds, strongly suggesting that there is still much to be explored concerning CaCC in smooth muscle.Susan WrayClodagh PrendergastSarah ArrowsmithFrontiers Media S.A.articlecalcium-activated chloride channelsvascular smooth musclemyometrial smooth muscleTMEM16AAnoctamin 1excitabilityPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium-activated chloride channels vascular smooth muscle myometrial smooth muscle TMEM16A Anoctamin 1 excitability Physiology QP1-981
spellingShingle	calcium-activated chloride channels vascular smooth muscle myometrial smooth muscle TMEM16A Anoctamin 1 excitability Physiology QP1-981 Susan Wray Clodagh Prendergast Sarah Arrowsmith Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
description	In smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major anionic channel. Opening of these channels leads to chloride efflux and depolarization of the myocyte membrane. In this way, activation of the channels by a rise of intracellular [Ca2+], from a variety of sources, produces increased excitability and can initiate action potentials and contraction or increased tone. We now have a good mechanistic understanding of how the channels are activated and regulated, due to identification of TMEM16A (ANO1) as the molecular entity of the channel, but key questions remain. In reviewing these channels and comparing two distinct smooth muscles, myometrial and vascular, we expose the differences that occur in their activation mechanisms, properties, and control. We find that the myometrium only expresses “classical,” Ca2+-activated, and voltage sensitive channels, whereas both tonic and phasic blood vessels express classical, and non-classical, cGMP-regulated CaCC, which are voltage insensitive. This translates to more complex activation and regulation in vascular smooth muscles, irrespective of whether they are tonic or phasic. We therefore tentatively conclude that although these channels are expressed and functionally important in all smooth muscles, they are probably not part of the mechanisms governing phasic activity. Recent knockdown studies have produced unexpected functional results, e.g. no effects on labour and delivery, and tone increasing in some but decreasing in other vascular beds, strongly suggesting that there is still much to be explored concerning CaCC in smooth muscle.
format	article
author	Susan Wray Clodagh Prendergast Sarah Arrowsmith
author_facet	Susan Wray Clodagh Prendergast Sarah Arrowsmith
author_sort	Susan Wray
title	Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
title_short	Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
title_full	Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
title_fullStr	Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
title_full_unstemmed	Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle
title_sort	calcium-activated chloride channels in myometrial and vascular smooth muscle
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2f988643e56549639d6acb4c8b3e7fa8
work_keys_str_mv	AT susanwray calciumactivatedchloridechannelsinmyometrialandvascularsmoothmuscle AT clodaghprendergast calciumactivatedchloridechannelsinmyometrialandvascularsmoothmuscle AT saraharrowsmith calciumactivatedchloridechannelsinmyometrialandvascularsmoothmuscle
_version_	1718426229169717248

Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle

Ejemplares similares