Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome

Dave S Ho,1 Okeanis E Vaou,1,2 Anna D Hohler2 1Neurology, Boston University School of Medicine, Boston, MA, USA; 2Steward Medical Group Neurology, St. Elizabeth’s Medical Center, Brighton, MA, USACorrespondence: Dave S HoBoston University School of Medicine, 1949 Commonwealth Ave, Apt 35,...

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Autores principales:	Ho DS, Vaou OE, Hohler AD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dry eye syndrome sjogren’s disease keratoconjunctivitis sicca sicca complex pots dysautonomia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2f99c3d3624e4defa4b2f57b6da0678c
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spelling	oai:doaj.org-article:2f99c3d3624e4defa4b2f57b6da0678c2021-12-02T13:38:21ZDry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome1177-5483https://doaj.org/article/2f99c3d3624e4defa4b2f57b6da0678c2020-11-01T00:00:00Zhttps://www.dovepress.com/dry-eye-syndrome-and-sicca-complex-are-commonly-found-in-patients-with-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Dave S Ho,1 Okeanis E Vaou,1,2 Anna D Hohler2 1Neurology, Boston University School of Medicine, Boston, MA, USA; 2Steward Medical Group Neurology, St. Elizabeth’s Medical Center, Brighton, MA, USACorrespondence: Dave S HoBoston University School of Medicine, 1949 Commonwealth Ave, Apt 35, Boston, MA, USATel +1 949 468 8797Fax +1 617 789 5177Email dave.ho@bmc.orgPurpose: Patients with postural orthostatic tachycardia syndrome (POTS) present to outpatient dysautonomia clinics endorsing a wide range of symptoms. Dry eyes and mouth, or sicca complex are frequently reported. This retrospective study investigates the incidence and quantifies the severity of dry eye syndrome (DES) in patients with POTS.Patients and Methods: This retrospective study compiles survey results, and dry eye clinical data from twenty-three POTS patients (22 females, average age 34.9 and st dev 14.0 years) surveyed during their initial or follow-up appointments. Patient’s medication lists were documented to account for anticholinergics, antihistamines, and anticholinesterase use. Patients endorsing dry eye symptoms were tested with Schirmer’s test strips to identify clinically dry eyes and stratified for severity.Results: Sixty-five percent of patients endorsed dry eye symptoms (15/23). Seventy-four percent of patients endorsed dry mouth symptoms (17/23). Among patients endorsing dry eyes, 81% of eyes had decreased tear production with Schirmer’s strip wetting less than 10 mm/5 min (13/16).Conclusion: DES is an additional and significant disease burden for the POTS patient population. Dry eye and exocrine gland function should be evaluated as part of the dysautonomia work up with referral to ophthalmology as appropriate. Patients with clinically dry eyes who report additional autonomic dysfunction should be further evaluated for widespread autonomic dysfunction.Keywords: dry eye syndrome, Sjogren’s disease, keratoconjunctivitis sicca, sicca complex, POTS, dysautonomiaHo DSVaou OEHohler ADDove Medical Pressarticledry eye syndromesjogren’s diseasekeratoconjunctivitis siccasicca complexpotsdysautonomiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4015-4021 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye syndrome sjogren’s disease keratoconjunctivitis sicca sicca complex pots dysautonomia Ophthalmology RE1-994
spellingShingle	dry eye syndrome sjogren’s disease keratoconjunctivitis sicca sicca complex pots dysautonomia Ophthalmology RE1-994 Ho DS Vaou OE Hohler AD Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
description	Dave S Ho,1 Okeanis E Vaou,1,2 Anna D Hohler2 1Neurology, Boston University School of Medicine, Boston, MA, USA; 2Steward Medical Group Neurology, St. Elizabeth’s Medical Center, Brighton, MA, USACorrespondence: Dave S HoBoston University School of Medicine, 1949 Commonwealth Ave, Apt 35, Boston, MA, USATel +1 949 468 8797Fax +1 617 789 5177Email dave.ho@bmc.orgPurpose: Patients with postural orthostatic tachycardia syndrome (POTS) present to outpatient dysautonomia clinics endorsing a wide range of symptoms. Dry eyes and mouth, or sicca complex are frequently reported. This retrospective study investigates the incidence and quantifies the severity of dry eye syndrome (DES) in patients with POTS.Patients and Methods: This retrospective study compiles survey results, and dry eye clinical data from twenty-three POTS patients (22 females, average age 34.9 and st dev 14.0 years) surveyed during their initial or follow-up appointments. Patient’s medication lists were documented to account for anticholinergics, antihistamines, and anticholinesterase use. Patients endorsing dry eye symptoms were tested with Schirmer’s test strips to identify clinically dry eyes and stratified for severity.Results: Sixty-five percent of patients endorsed dry eye symptoms (15/23). Seventy-four percent of patients endorsed dry mouth symptoms (17/23). Among patients endorsing dry eyes, 81% of eyes had decreased tear production with Schirmer’s strip wetting less than 10 mm/5 min (13/16).Conclusion: DES is an additional and significant disease burden for the POTS patient population. Dry eye and exocrine gland function should be evaluated as part of the dysautonomia work up with referral to ophthalmology as appropriate. Patients with clinically dry eyes who report additional autonomic dysfunction should be further evaluated for widespread autonomic dysfunction.Keywords: dry eye syndrome, Sjogren’s disease, keratoconjunctivitis sicca, sicca complex, POTS, dysautonomia
format	article
author	Ho DS Vaou OE Hohler AD
author_facet	Ho DS Vaou OE Hohler AD
author_sort	Ho DS
title	Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
title_short	Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
title_full	Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
title_fullStr	Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
title_full_unstemmed	Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome
title_sort	dry eye syndrome and sicca complex are commonly found in patients with postural orthostatic tachycardia syndrome
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2f99c3d3624e4defa4b2f57b6da0678c
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Dry Eye Syndrome and Sicca Complex are Commonly Found in Patients with Postural Orthostatic Tachycardia Syndrome

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