Current views on the pharmacological correction of iron deficiency conditions in gynecological practice

The review considers features of iron and folic acid (FA) pharmacokinetics, which affect the effective micronutrient support: molecular mechanisms of absorption and distribution, homeostatic processes of maintaining plasma vitamin and mineral levels by the feedback mechanism, including by regulating...

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Autor principal:	Aleksandr S. Dukhanin
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	micronutrients ferrokinetics systemic ferrotherapy oral iron preparations folic acid synergism combined preparations Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/2f9a2bd865564190bd7359253543bb2b
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spelling	oai:doaj.org-article:2f9a2bd865564190bd7359253543bb2b2021-12-02T19:22:24ZCurrent views on the pharmacological correction of iron deficiency conditions in gynecological practice2079-56962079-583110.26442/20795696.2021.4.201064https://doaj.org/article/2f9a2bd865564190bd7359253543bb2b2021-09-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/80181/60723https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831The review considers features of iron and folic acid (FA) pharmacokinetics, which affect the effective micronutrient support: molecular mechanisms of absorption and distribution, homeostatic processes of maintaining plasma vitamin and mineral levels by the feedback mechanism, including by regulating the deposition. An important characteristic of ferrokinetics is the presence of unique iron exporter ferroportin which is controlled by a family of iron regulatory proteins. Systemic ferrotherapy and oral rout of iron delivery are distinguished. In general, parenteral iron preparation complexes consist of Fe(III) oxide/hydroxide core stabilized by a carbohydrate polymer shell. Once entering the bloodstream, iron complexes are absorbed by resident macrophages of the reticuloendothelial system of the liver, spleen and bone marrow. Systemic Fe(III) preparations are prodrugs, the active part of which, i.e. iron is released in the lysosomal matrix of phagocytes. Oral iron preparations are divided into those containing bivalent (ferrous) and trivalent (ferric) iron. The article discusses factors determining the differences in the absorption of oral ferrous and ferric iron preparation, the spectrum of side effects, as well as key pharmaceutical approaches to increase the tolerance and adherence of ferrotherapy. These include using preparations containing Fe(II) organic compounds that have a lower dissociation rate than inorganic iron salts as well as slowing down the release of the active Fe(II) pharmaceutical substance from the drug. The review pays special attention to folates as iron synergists and examines the features of FA pharmacokinetics, the molecular basis of synergism, and substantiates the use of combined iron and FA preparations.Aleksandr S. DukhaninIP Berlin A.V. articlemicronutrientsferrokineticssystemic ferrotherapyoral iron preparationsfolic acidsynergismcombined preparationsGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 4, Pp 300-306 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	micronutrients ferrokinetics systemic ferrotherapy oral iron preparations folic acid synergism combined preparations Gynecology and obstetrics RG1-991
spellingShingle	micronutrients ferrokinetics systemic ferrotherapy oral iron preparations folic acid synergism combined preparations Gynecology and obstetrics RG1-991 Aleksandr S. Dukhanin Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
description	The review considers features of iron and folic acid (FA) pharmacokinetics, which affect the effective micronutrient support: molecular mechanisms of absorption and distribution, homeostatic processes of maintaining plasma vitamin and mineral levels by the feedback mechanism, including by regulating the deposition. An important characteristic of ferrokinetics is the presence of unique iron exporter ferroportin which is controlled by a family of iron regulatory proteins. Systemic ferrotherapy and oral rout of iron delivery are distinguished. In general, parenteral iron preparation complexes consist of Fe(III) oxide/hydroxide core stabilized by a carbohydrate polymer shell. Once entering the bloodstream, iron complexes are absorbed by resident macrophages of the reticuloendothelial system of the liver, spleen and bone marrow. Systemic Fe(III) preparations are prodrugs, the active part of which, i.e. iron is released in the lysosomal matrix of phagocytes. Oral iron preparations are divided into those containing bivalent (ferrous) and trivalent (ferric) iron. The article discusses factors determining the differences in the absorption of oral ferrous and ferric iron preparation, the spectrum of side effects, as well as key pharmaceutical approaches to increase the tolerance and adherence of ferrotherapy. These include using preparations containing Fe(II) organic compounds that have a lower dissociation rate than inorganic iron salts as well as slowing down the release of the active Fe(II) pharmaceutical substance from the drug. The review pays special attention to folates as iron synergists and examines the features of FA pharmacokinetics, the molecular basis of synergism, and substantiates the use of combined iron and FA preparations.
format	article
author	Aleksandr S. Dukhanin
author_facet	Aleksandr S. Dukhanin
author_sort	Aleksandr S. Dukhanin
title	Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
title_short	Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
title_full	Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
title_fullStr	Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
title_full_unstemmed	Current views on the pharmacological correction of iron deficiency conditions in gynecological practice
title_sort	current views on the pharmacological correction of iron deficiency conditions in gynecological practice
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/2f9a2bd865564190bd7359253543bb2b
work_keys_str_mv	AT aleksandrsdukhanin currentviewsonthepharmacologicalcorrectionofirondeficiencyconditionsingynecologicalpractice
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Current views on the pharmacological correction of iron deficiency conditions in gynecological practice

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