Cryo-EM structure of the human histamine H1 receptor/Gq complex

Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown. Here, the authors present the cryo-EM structure of histamine-bound H1R/Gq complex an...

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Autores principales:	Ruixue Xia, Na Wang, Zhenmei Xu, Yang Lu, Jing Song, Anqi Zhang, Changyou Guo, Yuanzheng He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f9a306097634cc2aff8113266df59fa
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spelling	oai:doaj.org-article:2f9a306097634cc2aff8113266df59fa2021-12-02T18:15:42ZCryo-EM structure of the human histamine H1 receptor/Gq complex10.1038/s41467-021-22427-22041-1723https://doaj.org/article/2f9a306097634cc2aff8113266df59fa2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22427-2https://doaj.org/toc/2041-1723Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown. Here, the authors present the cryo-EM structure of histamine-bound H1R/Gq complex and propose a mechanism of ligand induced receptor activation.Ruixue XiaNa WangZhenmei XuYang LuJing SongAnqi ZhangChangyou GuoYuanzheng HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruixue Xia Na Wang Zhenmei Xu Yang Lu Jing Song Anqi Zhang Changyou Guo Yuanzheng He Cryo-EM structure of the human histamine H1 receptor/Gq complex
description	Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown. Here, the authors present the cryo-EM structure of histamine-bound H1R/Gq complex and propose a mechanism of ligand induced receptor activation.
format	article
author	Ruixue Xia Na Wang Zhenmei Xu Yang Lu Jing Song Anqi Zhang Changyou Guo Yuanzheng He
author_facet	Ruixue Xia Na Wang Zhenmei Xu Yang Lu Jing Song Anqi Zhang Changyou Guo Yuanzheng He
author_sort	Ruixue Xia
title	Cryo-EM structure of the human histamine H1 receptor/Gq complex
title_short	Cryo-EM structure of the human histamine H1 receptor/Gq complex
title_full	Cryo-EM structure of the human histamine H1 receptor/Gq complex
title_fullStr	Cryo-EM structure of the human histamine H1 receptor/Gq complex
title_full_unstemmed	Cryo-EM structure of the human histamine H1 receptor/Gq complex
title_sort	cryo-em structure of the human histamine h1 receptor/gq complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f9a306097634cc2aff8113266df59fa
work_keys_str_mv	AT ruixuexia cryoemstructureofthehumanhistamineh1receptorgqcomplex AT nawang cryoemstructureofthehumanhistamineh1receptorgqcomplex AT zhenmeixu cryoemstructureofthehumanhistamineh1receptorgqcomplex AT yanglu cryoemstructureofthehumanhistamineh1receptorgqcomplex AT jingsong cryoemstructureofthehumanhistamineh1receptorgqcomplex AT anqizhang cryoemstructureofthehumanhistamineh1receptorgqcomplex AT changyouguo cryoemstructureofthehumanhistamineh1receptorgqcomplex AT yuanzhenghe cryoemstructureofthehumanhistamineh1receptorgqcomplex
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Cryo-EM structure of the human histamine H1 receptor/Gq complex

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