Targeting the microbiota to address diet-induced obesity: a time dependent challenge.

Links between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-...

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Autores principales:	Siobhan F Clarke, Eileen F Murphy, Orla O'Sullivan, R Paul Ross, Paul W O'Toole, Fergus Shanahan, Paul D Cotter
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f9eea6ac7de46ff933bf428c56ae119
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spelling	oai:doaj.org-article:2f9eea6ac7de46ff933bf428c56ae1192021-11-18T07:42:35ZTargeting the microbiota to address diet-induced obesity: a time dependent challenge.1932-620310.1371/journal.pone.0065790https://doaj.org/article/2f9eea6ac7de46ff933bf428c56ae1192013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762426/?tool=EBIhttps://doaj.org/toc/1932-6203Links between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-induced obese (DIO) mice through manipulation of the gut microbiota with vancomycin or with the bacteriocin-producing probiotic Lactobacillus salivarius UCC118 (Bac(+)), with metabolic improvement achieved in DIO mice in receipt of vancomycin. However, two phases of weight gain were observed with effects most marked early in the intervention phase. Here, we compare the gut microbial populations at the early relative to the late stages of intervention using a high throughput sequencing-based analysis to understand the temporal relationship between the gut microbiota and obesity. This reveals several differences in microbiota composition over the intervening period. Vancomycin dramatically altered the gut microbiota composition, relative to controls, at the early stages of intervention after which time some recovery was evident. It was also revealed that Bac(+) treatment initially resulted in the presence of significantly higher proportions of Peptococcaceae and significantly lower proportions of Rikenellaceae and Porphyromonadaceae relative to the gut microbiota of L. salivarius UCC118 bacteriocin negative (Bac(-)) administered controls. These differences were no longer evident at the later time. The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota.Siobhan F ClarkeEileen F MurphyOrla O'SullivanR Paul RossPaul W O'TooleFergus ShanahanPaul D CotterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65790 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siobhan F Clarke Eileen F Murphy Orla O'Sullivan R Paul Ross Paul W O'Toole Fergus Shanahan Paul D Cotter Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
description	Links between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-induced obese (DIO) mice through manipulation of the gut microbiota with vancomycin or with the bacteriocin-producing probiotic Lactobacillus salivarius UCC118 (Bac(+)), with metabolic improvement achieved in DIO mice in receipt of vancomycin. However, two phases of weight gain were observed with effects most marked early in the intervention phase. Here, we compare the gut microbial populations at the early relative to the late stages of intervention using a high throughput sequencing-based analysis to understand the temporal relationship between the gut microbiota and obesity. This reveals several differences in microbiota composition over the intervening period. Vancomycin dramatically altered the gut microbiota composition, relative to controls, at the early stages of intervention after which time some recovery was evident. It was also revealed that Bac(+) treatment initially resulted in the presence of significantly higher proportions of Peptococcaceae and significantly lower proportions of Rikenellaceae and Porphyromonadaceae relative to the gut microbiota of L. salivarius UCC118 bacteriocin negative (Bac(-)) administered controls. These differences were no longer evident at the later time. The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota.
format	article
author	Siobhan F Clarke Eileen F Murphy Orla O'Sullivan R Paul Ross Paul W O'Toole Fergus Shanahan Paul D Cotter
author_facet	Siobhan F Clarke Eileen F Murphy Orla O'Sullivan R Paul Ross Paul W O'Toole Fergus Shanahan Paul D Cotter
author_sort	Siobhan F Clarke
title	Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
title_short	Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
title_full	Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
title_fullStr	Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
title_full_unstemmed	Targeting the microbiota to address diet-induced obesity: a time dependent challenge.
title_sort	targeting the microbiota to address diet-induced obesity: a time dependent challenge.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2f9eea6ac7de46ff933bf428c56ae119
work_keys_str_mv	AT siobhanfclarke targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT eileenfmurphy targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT orlaosullivan targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT rpaulross targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT paulwotoole targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT fergusshanahan targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge AT pauldcotter targetingthemicrobiotatoaddressdietinducedobesityatimedependentchallenge
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Targeting the microbiota to address diet-induced obesity: a time dependent challenge.

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