Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

Shigeto Fujimura,1,2 Kohei Ueda,1 Yoko Nomura,1 Yasuo Yanagi3,4 1Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, 2Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan; 3Singapore Eye Research Institute, 4Medical Retina Department, Singapor...

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Autores principales:	Fujimura S, Ueda K, Nomura Y, Yanagi Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Lutein zeaxanthin docosahexaenoic acid macular pigment optical density age-related macular degeneration chronic central serous chorioretinopathy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2f9fd1f2e85946ddaadd513fdf2b3085
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spelling	oai:doaj.org-article:2f9fd1f2e85946ddaadd513fdf2b30852021-12-02T01:36:21ZPreliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density1177-5483https://doaj.org/article/2f9fd1f2e85946ddaadd513fdf2b30852016-10-01T00:00:00Zhttps://www.dovepress.com/preliminary-analysis-of-the-relationship-between-serum-lutein-and-zeax-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Shigeto Fujimura,1,2 Kohei Ueda,1 Yoko Nomura,1 Yasuo Yanagi3,4 1Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, 2Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan; 3Singapore Eye Research Institute, 4Medical Retina Department, Singapore National Eye Centre, Singapore Purpose: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD.Methods: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA. The best-corrected visual acuity and contrast sensitivity (CS) were measured at baseline and at 1, 3, and 6 months. Serum L+Z concentrations were measured at baseline and at 3 months. MPOD was calculated at each time point using fundus autofluorescent images.Results: Serum L+Z concentration was correlated with MPOD at 1°–2° eccentricity at baseline (r=0.63, P=0.003) and 3 months (r=0.53, P=0.015). Serum L+Z concentration increased by a factor of 2.3±1.0 (P<0.0001). At 6 months, MPOD was significantly higher compared to the baseline level at 0°–0.25° (P=0.034) and 0.25°–0.5° (P=0.032) eccentricity. CS improved after 3 or 6 months of L+Z+DHA supplementation (P<0.05).Conclusion: Juxtafoveal MPOD was associated with serum L+Z concentration. Foveal MPOD was increased by L+Z+DHA dietary supplementation. Keywords: fundus autofluorescence, supplement, spatial distributionFujimura SUeda KNomura YYanagi YDove Medical PressarticleLuteinzeaxanthindocosahexaenoic acidmacular pigment optical densityage-related macular degenerationchronic central serous chorioretinopathyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2149-2155 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lutein zeaxanthin docosahexaenoic acid macular pigment optical density age-related macular degeneration chronic central serous chorioretinopathy Ophthalmology RE1-994
spellingShingle	Lutein zeaxanthin docosahexaenoic acid macular pigment optical density age-related macular degeneration chronic central serous chorioretinopathy Ophthalmology RE1-994 Fujimura S Ueda K Nomura Y Yanagi Y Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
description	Shigeto Fujimura,1,2 Kohei Ueda,1 Yoko Nomura,1 Yasuo Yanagi3,4 1Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, 2Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan; 3Singapore Eye Research Institute, 4Medical Retina Department, Singapore National Eye Centre, Singapore Purpose: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD.Methods: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA. The best-corrected visual acuity and contrast sensitivity (CS) were measured at baseline and at 1, 3, and 6 months. Serum L+Z concentrations were measured at baseline and at 3 months. MPOD was calculated at each time point using fundus autofluorescent images.Results: Serum L+Z concentration was correlated with MPOD at 1°–2° eccentricity at baseline (r=0.63, P=0.003) and 3 months (r=0.53, P=0.015). Serum L+Z concentration increased by a factor of 2.3±1.0 (P<0.0001). At 6 months, MPOD was significantly higher compared to the baseline level at 0°–0.25° (P=0.034) and 0.25°–0.5° (P=0.032) eccentricity. CS improved after 3 or 6 months of L+Z+DHA supplementation (P<0.05).Conclusion: Juxtafoveal MPOD was associated with serum L+Z concentration. Foveal MPOD was increased by L+Z+DHA dietary supplementation. Keywords: fundus autofluorescence, supplement, spatial distribution
format	article
author	Fujimura S Ueda K Nomura Y Yanagi Y
author_facet	Fujimura S Ueda K Nomura Y Yanagi Y
author_sort	Fujimura S
title	Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
title_short	Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
title_full	Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
title_fullStr	Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
title_full_unstemmed	Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
title_sort	preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2f9fd1f2e85946ddaadd513fdf2b3085
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Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

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