Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats

Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g)...

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Autores principales:	Naser Hajizadeh, Gholam Hossein Farjah, Mojtaba Karimipour, Bagher Pourheidar
Formato:	article
Lenguaje:	EN
Publicado:	Guilan University of Medical Sciences 2021
Materias:	spinal cord injuries antioxidants ischemia reperfusion rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2fa411e41f2d4035b6113081424868d9
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spelling	oai:doaj.org-article:2fa411e41f2d4035b6113081424868d92021-11-23T12:24:50ZProtective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats10.32598/CJNS.7.27.42423-4818https://doaj.org/article/2fa411e41f2d4035b6113081424868d92021-10-01T00:00:00Zhttps://cjns.gums.ac.ir/article-1-465-en.htmlhttps://doaj.org/toc/2423-4818Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+10 mg/kg CH), and high-dose CH (I-R+20 mg/kg CH). Abdominal aorta clamping was done for 60 min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. 16 using ANOVA and Kruskal-Wallis and Mann-Whitney U tests. Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (20 mg/kg) group were lower than in the DMSO group (P=0.032). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P<0.05). The plasma level of Total Antioxidant Capacity (TAC) in the CH (20 mg/kg) group was higher than in the DMSO group (P=0.032). In addition, the plasma level of catalase in the CH (20 mg/kg) group was higher than in the DMSO and CH (10 mg/kg) groups (P<0.001). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P<0.001). Conclusion: These results showed that CH may be effective in reducing spinal cord I-R injury.Naser HajizadehGholam Hossein FarjahMojtaba KarimipourBagher PourheidarGuilan University of Medical Sciencesarticlespinal cord injuriesantioxidantsischemiareperfusionratsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENCaspian Journal of Neurological Sciences, Vol 7, Iss 4, Pp 193-201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injuries antioxidants ischemia reperfusion rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	spinal cord injuries antioxidants ischemia reperfusion rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Naser Hajizadeh Gholam Hossein Farjah Mojtaba Karimipour Bagher Pourheidar Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
description	Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+10 mg/kg CH), and high-dose CH (I-R+20 mg/kg CH). Abdominal aorta clamping was done for 60 min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. 16 using ANOVA and Kruskal-Wallis and Mann-Whitney U tests. Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (20 mg/kg) group were lower than in the DMSO group (P=0.032). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P<0.05). The plasma level of Total Antioxidant Capacity (TAC) in the CH (20 mg/kg) group was higher than in the DMSO group (P=0.032). In addition, the plasma level of catalase in the CH (20 mg/kg) group was higher than in the DMSO and CH (10 mg/kg) groups (P<0.001). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P<0.001). Conclusion: These results showed that CH may be effective in reducing spinal cord I-R injury.
format	article
author	Naser Hajizadeh Gholam Hossein Farjah Mojtaba Karimipour Bagher Pourheidar
author_facet	Naser Hajizadeh Gholam Hossein Farjah Mojtaba Karimipour Bagher Pourheidar
author_sort	Naser Hajizadeh
title	Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
title_short	Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
title_full	Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
title_fullStr	Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
title_full_unstemmed	Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
title_sort	protective effect of catechin hydrate on spinal cord ischemia-reperfusion injury in rats
publisher	Guilan University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/2fa411e41f2d4035b6113081424868d9
work_keys_str_mv	AT naserhajizadeh protectiveeffectofcatechinhydrateonspinalcordischemiareperfusioninjuryinrats AT gholamhosseinfarjah protectiveeffectofcatechinhydrateonspinalcordischemiareperfusioninjuryinrats AT mojtabakarimipour protectiveeffectofcatechinhydrateonspinalcordischemiareperfusioninjuryinrats AT bagherpourheidar protectiveeffectofcatechinhydrateonspinalcordischemiareperfusioninjuryinrats
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Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats

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