A previously unknown way of heme detoxification in the digestive tract of cats

Abstract Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone...

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Autores principales:	Alexandr B. Duzhak, Petr S. Sherin, Vadim V. Yanshole, Sergey L. Veber, Sergey I. Baiborodin, Olga I. Sinitsyna, Yuri P. Tsentalovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fa49d49aade40c9b617958059de1827
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spelling	oai:doaj.org-article:2fa49d49aade40c9b617958059de18272021-12-02T15:51:15ZA previously unknown way of heme detoxification in the digestive tract of cats10.1038/s41598-021-87421-62045-2322https://doaj.org/article/2fa49d49aade40c9b617958059de18272021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87421-6https://doaj.org/toc/2045-2322Abstract Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone of this process is the encapsulation of heme into carbonated hydroxyapatite nanoparticles, followed by their excretion with faeces. This way of heme neutralization resembles the formation of insoluble heme-containing particles in the digestive tracts of other hematophagous species (for example, the formation of insoluble hemozoin crystals in malaria-causing Plasmodium parasites). Our findings suggest that the encapsulation of heme molecules into a hydroxyapatite matrix occurs during the transition from the acidic gastric juice to the small intestine with neutral conditions. The formation of these particles and their efficiency to include heme depends on the bone content in a cat’s diet. In vitro experiments with heme-hydroxyapatite nanoparticles confirm the proposed scenario.Alexandr B. DuzhakPetr S. SherinVadim V. YansholeSergey L. VeberSergey I. BaiborodinOlga I. SinitsynaYuri P. TsentalovichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandr B. Duzhak Petr S. Sherin Vadim V. Yanshole Sergey L. Veber Sergey I. Baiborodin Olga I. Sinitsyna Yuri P. Tsentalovich A previously unknown way of heme detoxification in the digestive tract of cats
description	Abstract Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone of this process is the encapsulation of heme into carbonated hydroxyapatite nanoparticles, followed by their excretion with faeces. This way of heme neutralization resembles the formation of insoluble heme-containing particles in the digestive tracts of other hematophagous species (for example, the formation of insoluble hemozoin crystals in malaria-causing Plasmodium parasites). Our findings suggest that the encapsulation of heme molecules into a hydroxyapatite matrix occurs during the transition from the acidic gastric juice to the small intestine with neutral conditions. The formation of these particles and their efficiency to include heme depends on the bone content in a cat’s diet. In vitro experiments with heme-hydroxyapatite nanoparticles confirm the proposed scenario.
format	article
author	Alexandr B. Duzhak Petr S. Sherin Vadim V. Yanshole Sergey L. Veber Sergey I. Baiborodin Olga I. Sinitsyna Yuri P. Tsentalovich
author_facet	Alexandr B. Duzhak Petr S. Sherin Vadim V. Yanshole Sergey L. Veber Sergey I. Baiborodin Olga I. Sinitsyna Yuri P. Tsentalovich
author_sort	Alexandr B. Duzhak
title	A previously unknown way of heme detoxification in the digestive tract of cats
title_short	A previously unknown way of heme detoxification in the digestive tract of cats
title_full	A previously unknown way of heme detoxification in the digestive tract of cats
title_fullStr	A previously unknown way of heme detoxification in the digestive tract of cats
title_full_unstemmed	A previously unknown way of heme detoxification in the digestive tract of cats
title_sort	previously unknown way of heme detoxification in the digestive tract of cats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fa49d49aade40c9b617958059de1827
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A previously unknown way of heme detoxification in the digestive tract of cats

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