Development of devices for self-injection: using tribological analysis to optimize injection force

Jakob Lange, Leos Urbanek, Stefan BurrenYpsomed Delivery Systems, Ypsomed AG, Burgdorf, Switzerland Abstract: This article describes the use of analytical models and physical measurements to characterize and optimize the tribological behavior of pen injectors for self-administratio...

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Autores principales:	Lange J, Urbanek L, Burren S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Injection pen injection force efficiency coefficient of friction lubrication testing material selection. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/2fa4d33fabf543dca40a4d3f84186b67
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spelling	oai:doaj.org-article:2fa4d33fabf543dca40a4d3f84186b672021-12-02T07:54:52ZDevelopment of devices for self-injection: using tribological analysis to optimize injection force1179-1470https://doaj.org/article/2fa4d33fabf543dca40a4d3f84186b672016-05-01T00:00:00Zhttps://www.dovepress.com/development-of-devices-for-self-injection-using-tribological-analysis--peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Jakob Lange, Leos Urbanek, Stefan BurrenYpsomed Delivery Systems, Ypsomed AG, Burgdorf, Switzerland Abstract: This article describes the use of analytical models and physical measurements to characterize and optimize the tribological behavior of pen injectors for self-administration of biopharmaceuticals. One of the main performance attributes of this kind of device is its efficiency in transmitting the external force applied by the user on to the cartridge inside the pen in order to effectuate an injection. This injection force characteristic is heavily influenced by the frictional properties of the polymeric materials employed in the mechanism. Standard friction tests are available for characterizing candidate materials, but they use geometries and conditions far removed from the actual situation inside a pen injector and thus do not always generate relevant data. A new test procedure, allowing the direct measurement of the coefficient of friction between two key parts of a pen injector mechanism using real parts under simulated use conditions, is presented. In addition to the absolute level of friction, the test method provides information on expected evolution of friction over lifetime as well as on expected consistency between individual devices. Paired with an analytical model of the pen mechanism, the frictional data allow the expected overall injection system force efficiency to be estimated. The test method and analytical model are applied to a range of polymer combinations with different kinds of lubrication. It is found that material combinations used without lubrication generally have unsatisfactory performance, that the use of silicone-based internal lubricating additives improves performance, and that the best results can be achieved with external silicone-based lubricants. Polytetrafluoroethylene-based internal lubrication and external lubrication are also evaluated but found to provide only limited benefits unless used in combination with silicone. Keywords: injection pen, injection force efficiency, coefficient of friction, lubrication, testing, material selectionLange JUrbanek LBurren SDove Medical PressarticleInjection peninjection force efficiencycoefficient of frictionlubricationtestingmaterial selection.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2016, Iss Issue 1, Pp 93-103 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Injection pen injection force efficiency coefficient of friction lubrication testing material selection. Medical technology R855-855.5
spellingShingle	Injection pen injection force efficiency coefficient of friction lubrication testing material selection. Medical technology R855-855.5 Lange J Urbanek L Burren S Development of devices for self-injection: using tribological analysis to optimize injection force
description	Jakob Lange, Leos Urbanek, Stefan BurrenYpsomed Delivery Systems, Ypsomed AG, Burgdorf, Switzerland Abstract: This article describes the use of analytical models and physical measurements to characterize and optimize the tribological behavior of pen injectors for self-administration of biopharmaceuticals. One of the main performance attributes of this kind of device is its efficiency in transmitting the external force applied by the user on to the cartridge inside the pen in order to effectuate an injection. This injection force characteristic is heavily influenced by the frictional properties of the polymeric materials employed in the mechanism. Standard friction tests are available for characterizing candidate materials, but they use geometries and conditions far removed from the actual situation inside a pen injector and thus do not always generate relevant data. A new test procedure, allowing the direct measurement of the coefficient of friction between two key parts of a pen injector mechanism using real parts under simulated use conditions, is presented. In addition to the absolute level of friction, the test method provides information on expected evolution of friction over lifetime as well as on expected consistency between individual devices. Paired with an analytical model of the pen mechanism, the frictional data allow the expected overall injection system force efficiency to be estimated. The test method and analytical model are applied to a range of polymer combinations with different kinds of lubrication. It is found that material combinations used without lubrication generally have unsatisfactory performance, that the use of silicone-based internal lubricating additives improves performance, and that the best results can be achieved with external silicone-based lubricants. Polytetrafluoroethylene-based internal lubrication and external lubrication are also evaluated but found to provide only limited benefits unless used in combination with silicone. Keywords: injection pen, injection force efficiency, coefficient of friction, lubrication, testing, material selection
format	article
author	Lange J Urbanek L Burren S
author_facet	Lange J Urbanek L Burren S
author_sort	Lange J
title	Development of devices for self-injection: using tribological analysis to optimize injection force
title_short	Development of devices for self-injection: using tribological analysis to optimize injection force
title_full	Development of devices for self-injection: using tribological analysis to optimize injection force
title_fullStr	Development of devices for self-injection: using tribological analysis to optimize injection force
title_full_unstemmed	Development of devices for self-injection: using tribological analysis to optimize injection force
title_sort	development of devices for self-injection: using tribological analysis to optimize injection force
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2fa4d33fabf543dca40a4d3f84186b67
work_keys_str_mv	AT langej developmentofdevicesforselfinjectionusingtribologicalanalysistooptimizeinjectionforce AT urbanekl developmentofdevicesforselfinjectionusingtribologicalanalysistooptimizeinjectionforce AT burrens developmentofdevicesforselfinjectionusingtribologicalanalysistooptimizeinjectionforce
_version_	1718399091585581056

Development of devices for self-injection: using tribological analysis to optimize injection force

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