Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection

Abstract A gold standard for diagnosis of periprosthetic joint infection (PJI) has not yet been established. The objective of this study was to evaluate the diagnostic value of serum and synovial fluid interleukin (IL)-6 levels for PJI. The MEDLINE and EMBASE databases were searched for studies desc...

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Autores principales:	Kai Xie, Kerong Dai, Xinhua Qu, Mengning Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fa63580cf50411295e8cb6dc6cd9942
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spelling	oai:doaj.org-article:2fa63580cf50411295e8cb6dc6cd99422021-12-02T15:05:57ZSerum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection10.1038/s41598-017-01713-42045-2322https://doaj.org/article/2fa63580cf50411295e8cb6dc6cd99422017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01713-4https://doaj.org/toc/2045-2322Abstract A gold standard for diagnosis of periprosthetic joint infection (PJI) has not yet been established. The objective of this study was to evaluate the diagnostic value of serum and synovial fluid interleukin (IL)-6 levels for PJI. The MEDLINE and EMBASE databases were searched for studies describing PJI diagnosis using serum and synovial fluid IL-6 and published between January 1990 and October 2016. Seventeen studies were included in the analysis. The pooled sensitivities of serum and synovial fluid IL-6 were 0.72 (95% confidence interval [CI]: 0.63–0.80) and 0.91 (95% CI: 0.82–0.96), respectively. The pooled specificities of serum and synovial fluid IL-6 were 0.89 (95% CI: 0.77–0.95) and 0.90 (95% CI: 0.84–0.95), respectively. The pooled diagnostic odds ratios (DORs) of serum and synovial fluid IL-6 were 20 (95% CI: 7–58) and 101 (95% CI: 28–358), respectively, and the pooled areas under the curve (AUCs) were 0.83 (95% CI: 0.79–0.86) and 0.96 (95% CI: 0.94–0.98), respectively. Synovial fluid IL-6 had high diagnostic value for PJI. Although serum IL-6 test was less sensitive than synovial fluid IL-6 test, it may be regularly prescribed for patients with prosthetic failure owing to its high specificity.Kai XieKerong DaiXinhua QuMengning YanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Xie Kerong Dai Xinhua Qu Mengning Yan Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
description	Abstract A gold standard for diagnosis of periprosthetic joint infection (PJI) has not yet been established. The objective of this study was to evaluate the diagnostic value of serum and synovial fluid interleukin (IL)-6 levels for PJI. The MEDLINE and EMBASE databases were searched for studies describing PJI diagnosis using serum and synovial fluid IL-6 and published between January 1990 and October 2016. Seventeen studies were included in the analysis. The pooled sensitivities of serum and synovial fluid IL-6 were 0.72 (95% confidence interval [CI]: 0.63–0.80) and 0.91 (95% CI: 0.82–0.96), respectively. The pooled specificities of serum and synovial fluid IL-6 were 0.89 (95% CI: 0.77–0.95) and 0.90 (95% CI: 0.84–0.95), respectively. The pooled diagnostic odds ratios (DORs) of serum and synovial fluid IL-6 were 20 (95% CI: 7–58) and 101 (95% CI: 28–358), respectively, and the pooled areas under the curve (AUCs) were 0.83 (95% CI: 0.79–0.86) and 0.96 (95% CI: 0.94–0.98), respectively. Synovial fluid IL-6 had high diagnostic value for PJI. Although serum IL-6 test was less sensitive than synovial fluid IL-6 test, it may be regularly prescribed for patients with prosthetic failure owing to its high specificity.
format	article
author	Kai Xie Kerong Dai Xinhua Qu Mengning Yan
author_facet	Kai Xie Kerong Dai Xinhua Qu Mengning Yan
author_sort	Kai Xie
title	Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
title_short	Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
title_full	Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
title_fullStr	Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
title_full_unstemmed	Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection
title_sort	serum and synovial fluid interleukin-6 for the diagnosis of periprosthetic joint infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2fa63580cf50411295e8cb6dc6cd9942
work_keys_str_mv	AT kaixie serumandsynovialfluidinterleukin6forthediagnosisofperiprostheticjointinfection AT kerongdai serumandsynovialfluidinterleukin6forthediagnosisofperiprostheticjointinfection AT xinhuaqu serumandsynovialfluidinterleukin6forthediagnosisofperiprostheticjointinfection AT mengningyan serumandsynovialfluidinterleukin6forthediagnosisofperiprostheticjointinfection
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Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection

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