Triple negative breast cancer: an Indian perspective

Murtaza Akhtar, Subhrajit Dasgupta, Murtuza Rangwala Department of Surgery, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India Introduction: Breast cancer is the most common female cancer in the world. Triple negative breast cancer (TNBC) is a recently identifie...

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Autores principales:	Akhtar M, Dasgupta S, Rangwala M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2fa7df270451482da94095c8f7318016
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spelling	oai:doaj.org-article:2fa7df270451482da94095c8f73180162021-12-02T02:41:53ZTriple negative breast cancer: an Indian perspective1179-1314https://doaj.org/article/2fa7df270451482da94095c8f73180162015-08-01T00:00:00Zhttp://www.dovepress.com/triple-negative-breast-cancer-an-indian-perspective-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Murtaza Akhtar, Subhrajit Dasgupta, Murtuza Rangwala Department of Surgery, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India Introduction: Breast cancer is the most common female cancer in the world. Triple negative breast cancer (TNBC) is a recently identified biological variant with aggressive tumor behavior and poor prognosis. Data of hormonal status from the Indian population is scarce due to financial constraints in performing immunohistochemistry evaluation. The present study aims to prospectively analyze receptor status of all breast cancer patients and identify TNBC and compare their clinical profile and short term survival with other non-TNBC group. Materials and methods: All cytologically and histopathologically confirmed cases of carcinoma breast were prospectively enrolled. In a longitudinal study at tertiary care hospital in central India based on the hormonal status, they were further divided into TNBC and other groups. Comparison of risk factors, clinical profile and short-term survival was carried out. Results: A total 85 patients were enrolled and of them 37 (43.7%) were TNBC. On comparing risk factors ie, age, age at menarche, total reproductive age, age at first child birth, and menopausal status – no statistical significance was observed between the TNBC and non-TNBC groups. But on comparison of clinical profile TNBC tumors were significantly large with majority of patients presenting as locally advanced breast cancer (83%). No statistical difference was observed in axillary lymph node status between two groups. TNBC tumors were histologically more aggressive (grade 3) compared to other groups. No statistically significant difference was observed in short term overall survival but all three deaths were observed in the TNBC group only and two local recurrences after surgery were observed in the TNBC group. Conclusion: TNBC forms a large proportion of carcinoma breast patients in a central Indian scenario and needs more research to identify appropriate treatment planning considering aggressive histology and advanced presentation. Keywords: triple negative breast cancer, TNBC, hormone receptor, breast cancer, ER, PR, HER2neuAkhtar MDasgupta SRangwala MDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 239-243 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Akhtar M Dasgupta S Rangwala M Triple negative breast cancer: an Indian perspective
description	Murtaza Akhtar, Subhrajit Dasgupta, Murtuza Rangwala Department of Surgery, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India Introduction: Breast cancer is the most common female cancer in the world. Triple negative breast cancer (TNBC) is a recently identified biological variant with aggressive tumor behavior and poor prognosis. Data of hormonal status from the Indian population is scarce due to financial constraints in performing immunohistochemistry evaluation. The present study aims to prospectively analyze receptor status of all breast cancer patients and identify TNBC and compare their clinical profile and short term survival with other non-TNBC group. Materials and methods: All cytologically and histopathologically confirmed cases of carcinoma breast were prospectively enrolled. In a longitudinal study at tertiary care hospital in central India based on the hormonal status, they were further divided into TNBC and other groups. Comparison of risk factors, clinical profile and short-term survival was carried out. Results: A total 85 patients were enrolled and of them 37 (43.7%) were TNBC. On comparing risk factors ie, age, age at menarche, total reproductive age, age at first child birth, and menopausal status – no statistical significance was observed between the TNBC and non-TNBC groups. But on comparison of clinical profile TNBC tumors were significantly large with majority of patients presenting as locally advanced breast cancer (83%). No statistical difference was observed in axillary lymph node status between two groups. TNBC tumors were histologically more aggressive (grade 3) compared to other groups. No statistically significant difference was observed in short term overall survival but all three deaths were observed in the TNBC group only and two local recurrences after surgery were observed in the TNBC group. Conclusion: TNBC forms a large proportion of carcinoma breast patients in a central Indian scenario and needs more research to identify appropriate treatment planning considering aggressive histology and advanced presentation. Keywords: triple negative breast cancer, TNBC, hormone receptor, breast cancer, ER, PR, HER2neu
format	article
author	Akhtar M Dasgupta S Rangwala M
author_facet	Akhtar M Dasgupta S Rangwala M
author_sort	Akhtar M
title	Triple negative breast cancer: an Indian perspective
title_short	Triple negative breast cancer: an Indian perspective
title_full	Triple negative breast cancer: an Indian perspective
title_fullStr	Triple negative breast cancer: an Indian perspective
title_full_unstemmed	Triple negative breast cancer: an Indian perspective
title_sort	triple negative breast cancer: an indian perspective
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/2fa7df270451482da94095c8f7318016
work_keys_str_mv	AT akhtarm triplenegativebreastcanceranindianperspective AT dasguptas triplenegativebreastcanceranindianperspective AT rangwalam triplenegativebreastcanceranindianperspective
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Triple negative breast cancer: an Indian perspective

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