Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

Strawberries, a popularly consumed berry fruit, are rich in bioactive compounds with antioxidant effects. In this study, we examined the effects of two dietary achievable doses of strawberries on the antioxidant status and biomarkers of endothelial function in adults with features of metabolic syndr...

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Autores principales:	Arpita Basu, Kenneth Izuora, Nancy M. Betts, Jeffrey L. Ebersole, Robert Hal Scofield
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	strawberries cardiometabolic superoxide dismutase antioxidant status adhesion molecules Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2faa960191c64d37b73cfaf3be5a7266
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spelling	oai:doaj.org-article:2faa960191c64d37b73cfaf3be5a72662021-11-25T16:27:22ZDietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial10.3390/antiox101117302076-3921https://doaj.org/article/2faa960191c64d37b73cfaf3be5a72662021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1730https://doaj.org/toc/2076-3921Strawberries, a popularly consumed berry fruit, are rich in bioactive compounds with antioxidant effects. In this study, we examined the effects of two dietary achievable doses of strawberries on the antioxidant status and biomarkers of endothelial function in adults with features of metabolic syndrome and a confirmed low baseline of fruit and vegetable intake. In a 14-week randomized controlled crossover study, participants were assigned to one of three groups for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples and health data were collected at baseline and at the end of each four-week phase of intervention. Thirty-three participants completed all three phases of the trial. Significant increases were observed in serum antioxidant capacity and superoxide dismutase activity as well as decreases in lipid peroxidation after both low and high dose strawberry phases when compared with the control phase. Significant decreases were also observed in soluble vascular cell adhesion molecule-1 and tumor necrosis factor-α with the high dose strawberry phase. These data confirm that consuming strawberries for four weeks significantly improves antioxidant status, endothelial function, and inflammation in adults with cardiometabolic risks.Arpita BasuKenneth IzuoraNancy M. BettsJeffrey L. EbersoleRobert Hal ScofieldMDPI AGarticlestrawberriescardiometabolicsuperoxide dismutaseantioxidant statusadhesion moleculesTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1730, p 1730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	strawberries cardiometabolic superoxide dismutase antioxidant status adhesion molecules Therapeutics. Pharmacology RM1-950
spellingShingle	strawberries cardiometabolic superoxide dismutase antioxidant status adhesion molecules Therapeutics. Pharmacology RM1-950 Arpita Basu Kenneth Izuora Nancy M. Betts Jeffrey L. Ebersole Robert Hal Scofield Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
description	Strawberries, a popularly consumed berry fruit, are rich in bioactive compounds with antioxidant effects. In this study, we examined the effects of two dietary achievable doses of strawberries on the antioxidant status and biomarkers of endothelial function in adults with features of metabolic syndrome and a confirmed low baseline of fruit and vegetable intake. In a 14-week randomized controlled crossover study, participants were assigned to one of three groups for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples and health data were collected at baseline and at the end of each four-week phase of intervention. Thirty-three participants completed all three phases of the trial. Significant increases were observed in serum antioxidant capacity and superoxide dismutase activity as well as decreases in lipid peroxidation after both low and high dose strawberry phases when compared with the control phase. Significant decreases were also observed in soluble vascular cell adhesion molecule-1 and tumor necrosis factor-α with the high dose strawberry phase. These data confirm that consuming strawberries for four weeks significantly improves antioxidant status, endothelial function, and inflammation in adults with cardiometabolic risks.
format	article
author	Arpita Basu Kenneth Izuora Nancy M. Betts Jeffrey L. Ebersole Robert Hal Scofield
author_facet	Arpita Basu Kenneth Izuora Nancy M. Betts Jeffrey L. Ebersole Robert Hal Scofield
author_sort	Arpita Basu
title	Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
title_short	Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
title_full	Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
title_fullStr	Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
title_full_unstemmed	Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial
title_sort	dietary strawberries improve biomarkers of antioxidant status and endothelial function in adults with cardiometabolic risks in a randomized controlled crossover trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2faa960191c64d37b73cfaf3be5a7266
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Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

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