Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke

Wen-Jie Wang,1 Tian-Jie Lyu,2,3 Zixiao Li1– 5 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of Chi...

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Autores principales:	Wang WJ, Lyu TJ, Li Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	patj cell polarity stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2fab2401086d42939470d384eb126a25
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spelling	oai:doaj.org-article:2fab2401086d42939470d384eb126a252021-12-02T16:33:32ZResearch Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke1178-2021https://doaj.org/article/2fab2401086d42939470d384eb126a252021-08-01T00:00:00Zhttps://www.dovepress.com/research-progress-on-patj-and-underlying-mechanisms-associated-with-fu-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Wen-Jie Wang,1 Tian-Jie Lyu,2,3 Zixiao Li1– 5 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of China; 3National Center for Healthcare Quality Management in Neurological Diseases, Beijing, 100070, People’s Republic of China; 4Chinese Institute for Brain Research, Beijing, 100070, People’s Republic of China; 5Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, 100070, People’s Republic of ChinaCorrespondence: Zixiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Chinese Institute for Brain Research, No. 119 West Road, Southern Fourth Ring Road, Beijing, 100070, People’s Republic of ChinaTel +86-1059978350Fax +86-1059973383Email lizixiao2008@hotmail.comAbstract: Cell polarity is an intrinsic property of epithelial cells regulated by scaffold proteins. The CRB (crumbs) complex is known to play a predominant role in the dynamic cooperative network of polarity scaffold proteins. PATJ (PALS1-associated tight junction) is the core component in the CRB complex and has been highly conserved throughout evolution. PATJ is crucial to several important events in organisms’ survival, including embryonic development, cell polarity, and barrier establishment. A recent study shows that PATJ plays an important role in functional outcomes of stroke. In this article, we elaborate on the biological structure and physiological functions of PATJ and explore the underlying mechanisms of PATJ genetic polymorphism that are associated with poor functional outcomes in ischemic stroke.Keywords: PATJ, cell polarity, strokeWang WJLyu TJLi ZDove Medical Pressarticlepatjcell polaritystrokeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2811-2818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	patj cell polarity stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	patj cell polarity stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang WJ Lyu TJ Li Z Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
description	Wen-Jie Wang,1 Tian-Jie Lyu,2,3 Zixiao Li1– 5 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of China; 3National Center for Healthcare Quality Management in Neurological Diseases, Beijing, 100070, People’s Republic of China; 4Chinese Institute for Brain Research, Beijing, 100070, People’s Republic of China; 5Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, 100070, People’s Republic of ChinaCorrespondence: Zixiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Chinese Institute for Brain Research, No. 119 West Road, Southern Fourth Ring Road, Beijing, 100070, People’s Republic of ChinaTel +86-1059978350Fax +86-1059973383Email lizixiao2008@hotmail.comAbstract: Cell polarity is an intrinsic property of epithelial cells regulated by scaffold proteins. The CRB (crumbs) complex is known to play a predominant role in the dynamic cooperative network of polarity scaffold proteins. PATJ (PALS1-associated tight junction) is the core component in the CRB complex and has been highly conserved throughout evolution. PATJ is crucial to several important events in organisms’ survival, including embryonic development, cell polarity, and barrier establishment. A recent study shows that PATJ plays an important role in functional outcomes of stroke. In this article, we elaborate on the biological structure and physiological functions of PATJ and explore the underlying mechanisms of PATJ genetic polymorphism that are associated with poor functional outcomes in ischemic stroke.Keywords: PATJ, cell polarity, stroke
format	article
author	Wang WJ Lyu TJ Li Z
author_facet	Wang WJ Lyu TJ Li Z
author_sort	Wang WJ
title	Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
title_short	Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
title_full	Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
title_fullStr	Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
title_full_unstemmed	Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
title_sort	research progress on patj and underlying mechanisms associated with functional outcomes after stroke
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2fab2401086d42939470d384eb126a25
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_version_	1718383742384340992

Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke

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