scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type...

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Autores principales:	Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
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spelling	oai:doaj.org-article:2fac3f5447844cbea3e21cfcf9b5423c2021-12-02T14:39:20ZscRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy10.1038/s41467-019-13657-62041-1723https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13657-6https://doaj.org/toc/2041-1723Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type specific.Jennifer OcasioBenjamin BabcockDaniel MalawskySeth J. WeirLipin LooJeremy M. SimonMark J. ZylkaDuhyeong HwangTaylor DismukeMarina SokolskyElias P. RosenRajeev VibhakarJiao ZhangOlivier SaulnierMaria VladoiuIbrahim El-HamamyLincoln D. SteinMichael D. TaylorKyle S. SmithPaul A. NorthcottAlejandro ColaneriKirk WilhelmsenTimothy R. GershonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer Ocasio Benjamin Babcock Daniel Malawsky Seth J. Weir Lipin Loo Jeremy M. Simon Mark J. Zylka Duhyeong Hwang Taylor Dismuke Marina Sokolsky Elias P. Rosen Rajeev Vibhakar Jiao Zhang Olivier Saulnier Maria Vladoiu Ibrahim El-Hamamy Lincoln D. Stein Michael D. Taylor Kyle S. Smith Paul A. Northcott Alejandro Colaneri Kirk Wilhelmsen Timothy R. Gershon scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
description	Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type specific.
format	article
author	Jennifer Ocasio Benjamin Babcock Daniel Malawsky Seth J. Weir Lipin Loo Jeremy M. Simon Mark J. Zylka Duhyeong Hwang Taylor Dismuke Marina Sokolsky Elias P. Rosen Rajeev Vibhakar Jiao Zhang Olivier Saulnier Maria Vladoiu Ibrahim El-Hamamy Lincoln D. Stein Michael D. Taylor Kyle S. Smith Paul A. Northcott Alejandro Colaneri Kirk Wilhelmsen Timothy R. Gershon
author_facet	Jennifer Ocasio Benjamin Babcock Daniel Malawsky Seth J. Weir Lipin Loo Jeremy M. Simon Mark J. Zylka Duhyeong Hwang Taylor Dismuke Marina Sokolsky Elias P. Rosen Rajeev Vibhakar Jiao Zhang Olivier Saulnier Maria Vladoiu Ibrahim El-Hamamy Lincoln D. Stein Michael D. Taylor Kyle S. Smith Paul A. Northcott Alejandro Colaneri Kirk Wilhelmsen Timothy R. Gershon
author_sort	Jennifer Ocasio
title	scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
title_short	scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
title_full	scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
title_fullStr	scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
title_full_unstemmed	scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
title_sort	scrna-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to shh inhibitor therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
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scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

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