An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant <named-content content-type="genus-species">Acinetobacter baumannii</named-content>-Infected Wounds

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant <named-content content-type="genus-species">Acinetobacter baumannii</named-content>-Infected Wounds

ABSTRACT The antibiotic paenimucillin A was originally identified using a culture-independent synthetic-bioinformatic natural product (syn-BNP) discovery approach. Here we report on a bioinformatics-guided survey of paenimucillin A analogs that led to the discovery of paenimucillin C. Paenimucillin...

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Autores principales: Xavier Vila-Farres, John Chu, Melinda A. Ternei, Christophe Lemetre, Steven Park, David S. Perlin, Sean F. Brady
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Acinetobacter baumannii
antibiotics
syn-BNP
wound infections
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/2fae744c0e1e459fa175a0b1daaaf57e
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