Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment

AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy...

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Autores principales:	Tae Heung Kang, Jung Hwa Park, Andrew Yang, Hyun Jin Park, Sung Eun Lee, Young Seob Kim, Gun-Young Jang, Emily Farmer, Brandon Lam, Yeong-Min Park, Chien-Fu Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fb1fbb0de664cbdac06f9837a479b3c
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spelling	oai:doaj.org-article:2fb1fbb0de664cbdac06f9837a479b3c2021-12-02T14:42:12ZAnnexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment10.1038/s41467-020-14821-z2041-1723https://doaj.org/article/2fb1fbb0de664cbdac06f9837a479b3c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14821-zhttps://doaj.org/toc/2041-1723AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy and with other immune checkpoint inhibitors.Tae Heung KangJung Hwa ParkAndrew YangHyun Jin ParkSung Eun LeeYoung Seob KimGun-Young JangEmily FarmerBrandon LamYeong-Min ParkChien-Fu HungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tae Heung Kang Jung Hwa Park Andrew Yang Hyun Jin Park Sung Eun Lee Young Seob Kim Gun-Young Jang Emily Farmer Brandon Lam Yeong-Min Park Chien-Fu Hung Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
description	AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy and with other immune checkpoint inhibitors.
format	article
author	Tae Heung Kang Jung Hwa Park Andrew Yang Hyun Jin Park Sung Eun Lee Young Seob Kim Gun-Young Jang Emily Farmer Brandon Lam Yeong-Min Park Chien-Fu Hung
author_facet	Tae Heung Kang Jung Hwa Park Andrew Yang Hyun Jin Park Sung Eun Lee Young Seob Kim Gun-Young Jang Emily Farmer Brandon Lam Yeong-Min Park Chien-Fu Hung
author_sort	Tae Heung Kang
title	Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
title_short	Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
title_full	Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
title_fullStr	Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
title_full_unstemmed	Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
title_sort	annexin a5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2fb1fbb0de664cbdac06f9837a479b3c
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Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment

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