Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment

AnnexinV has been shown to bind phosphatidylserine expressed by chemotherapy-induced apoptotic cells increasing their immunogeneicity. Here, the authors demonstrate in a preclinical tumor model that fusing tumor-antigen peptide to Annexin V enhances its efficacy when administered after chemotherapy...

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Autores principales: Tae Heung Kang, Jung Hwa Park, Andrew Yang, Hyun Jin Park, Sung Eun Lee, Young Seob Kim, Gun-Young Jang, Emily Farmer, Brandon Lam, Yeong-Min Park, Chien-Fu Hung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2fb1fbb0de664cbdac06f9837a479b3c
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