Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes
To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothe...
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Nature Portfolio
2021
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oai:doaj.org-article:2fb39cdda5f24d40a7fe8bfff1d6b4ac2021-12-02T16:13:26ZPlasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes10.1038/s41467-021-25062-z2041-1723https://doaj.org/article/2fb39cdda5f24d40a7fe8bfff1d6b4ac2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25062-zhttps://doaj.org/toc/2041-1723To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothelial cells associates with decreasing parasitaemia and less severe disease.Richard Thomson-LuqueLasse Votborg-NovélWanangwa NdovieCarolina M. AndradeMoussa NiangalyCharalampos AttipaNathalia F. LimaDrissa CoulibalyDidier DoumtabeBouréima GuindoBourama TangaraFayçal MaigaAbdoulaye Kassoum KoneKarim TraoreKassoum KayentaoAissata OngoibaSafiatou DoumboMahamadou A. TheraBoubacar TraoréKarl SeydelNuno S. OsórioSilvia PortugalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Richard Thomson-Luque Lasse Votborg-Novél Wanangwa Ndovie Carolina M. Andrade Moussa Niangaly Charalampos Attipa Nathalia F. Lima Drissa Coulibaly Didier Doumtabe Bouréima Guindo Bourama Tangara Fayçal Maiga Abdoulaye Kassoum Kone Karim Traore Kassoum Kayentao Aissata Ongoiba Safiatou Doumbo Mahamadou A. Thera Boubacar Traoré Karl Seydel Nuno S. Osório Silvia Portugal Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| description |
To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothelial cells associates with decreasing parasitaemia and less severe disease. |
| format |
article |
| author |
Richard Thomson-Luque Lasse Votborg-Novél Wanangwa Ndovie Carolina M. Andrade Moussa Niangaly Charalampos Attipa Nathalia F. Lima Drissa Coulibaly Didier Doumtabe Bouréima Guindo Bourama Tangara Fayçal Maiga Abdoulaye Kassoum Kone Karim Traore Kassoum Kayentao Aissata Ongoiba Safiatou Doumbo Mahamadou A. Thera Boubacar Traoré Karl Seydel Nuno S. Osório Silvia Portugal |
| author_facet |
Richard Thomson-Luque Lasse Votborg-Novél Wanangwa Ndovie Carolina M. Andrade Moussa Niangaly Charalampos Attipa Nathalia F. Lima Drissa Coulibaly Didier Doumtabe Bouréima Guindo Bourama Tangara Fayçal Maiga Abdoulaye Kassoum Kone Karim Traore Kassoum Kayentao Aissata Ongoiba Safiatou Doumbo Mahamadou A. Thera Boubacar Traoré Karl Seydel Nuno S. Osório Silvia Portugal |
| author_sort |
Richard Thomson-Luque |
| title |
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| title_short |
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| title_full |
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| title_fullStr |
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| title_full_unstemmed |
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| title_sort |
plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2fb39cdda5f24d40a7fe8bfff1d6b4ac |
| work_keys_str_mv |
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