A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial home...

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Autores principales: Yuanlong Hou, Wei Wei, Xiaojing Guan, Yali Liu, Gaorui Bian, Dandan He, Qilin Fan, Xiaoying Cai, Youying Zhang, Guangji Wang, Xiao Zheng, Haiping Hao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2fb63aca9bd948698496aea9f8a7359c
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Sumario:Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis.