A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial home...

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Autores principales: Yuanlong Hou, Wei Wei, Xiaojing Guan, Yali Liu, Gaorui Bian, Dandan He, Qilin Fan, Xiaoying Cai, Youying Zhang, Guangji Wang, Xiao Zheng, Haiping Hao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/2fb63aca9bd948698496aea9f8a7359c
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spelling oai:doaj.org-article:2fb63aca9bd948698496aea9f8a7359c2021-12-02T14:11:45ZA diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut10.1038/s41467-020-20673-42041-1723https://doaj.org/article/2fb63aca9bd948698496aea9f8a7359c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20673-4https://doaj.org/toc/2041-1723Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis.Yuanlong HouWei WeiXiaojing GuanYali LiuGaorui BianDandan HeQilin FanXiaoying CaiYouying ZhangGuangji WangXiao ZhengHaiping HaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuanlong Hou
Wei Wei
Xiaojing Guan
Yali Liu
Gaorui Bian
Dandan He
Qilin Fan
Xiaoying Cai
Youying Zhang
Guangji Wang
Xiao Zheng
Haiping Hao
A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
description Here, using a mouse model of chronic stress, the authors investigate how diet impacts stress and gut microbial structure and epithelial integrity and show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis.
format article
author Yuanlong Hou
Wei Wei
Xiaojing Guan
Yali Liu
Gaorui Bian
Dandan He
Qilin Fan
Xiaoying Cai
Youying Zhang
Guangji Wang
Xiao Zheng
Haiping Hao
author_facet Yuanlong Hou
Wei Wei
Xiaojing Guan
Yali Liu
Gaorui Bian
Dandan He
Qilin Fan
Xiaoying Cai
Youying Zhang
Guangji Wang
Xiao Zheng
Haiping Hao
author_sort Yuanlong Hou
title A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
title_short A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
title_full A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
title_fullStr A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
title_full_unstemmed A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
title_sort diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2fb63aca9bd948698496aea9f8a7359c
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