Disulfide disruption reverses mucus dysfunction in allergic airway disease

In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together reverses asthma-like obstruction in mice.

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Autores principales:	Leslie E. Morgan, Ana M. Jaramillo, Siddharth K. Shenoy, Dorota Raclawska, Nkechinyere A. Emezienna, Vanessa L. Richardson, Naoko Hara, Anna Q. Harder, James C. NeeDell, Corinne E. Hennessy, Hassan M. El-Batal, Chelsea M. Magin, Diane E. Grove Villalon, Gregg Duncan, Justin S. Hanes, Jung Soo Suk, David J. Thornton, Fernando Holguin, William J. Janssen, William R. Thelin, Christopher M. Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fb68d67a4a24797aac17403bb6726b1
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spelling	oai:doaj.org-article:2fb68d67a4a24797aac17403bb6726b12021-12-02T14:01:15ZDisulfide disruption reverses mucus dysfunction in allergic airway disease10.1038/s41467-020-20499-02041-1723https://doaj.org/article/2fb68d67a4a24797aac17403bb6726b12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20499-0https://doaj.org/toc/2041-1723In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together reverses asthma-like obstruction in mice.Leslie E. MorganAna M. JaramilloSiddharth K. ShenoyDorota RaclawskaNkechinyere A. EmeziennaVanessa L. RichardsonNaoko HaraAnna Q. HarderJames C. NeeDellCorinne E. HennessyHassan M. El-BatalChelsea M. MaginDiane E. Grove VillalonGregg DuncanJustin S. HanesJung Soo SukDavid J. ThorntonFernando HolguinWilliam J. JanssenWilliam R. ThelinChristopher M. EvansNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leslie E. Morgan Ana M. Jaramillo Siddharth K. Shenoy Dorota Raclawska Nkechinyere A. Emezienna Vanessa L. Richardson Naoko Hara Anna Q. Harder James C. NeeDell Corinne E. Hennessy Hassan M. El-Batal Chelsea M. Magin Diane E. Grove Villalon Gregg Duncan Justin S. Hanes Jung Soo Suk David J. Thornton Fernando Holguin William J. Janssen William R. Thelin Christopher M. Evans Disulfide disruption reverses mucus dysfunction in allergic airway disease
description	In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together reverses asthma-like obstruction in mice.
format	article
author	Leslie E. Morgan Ana M. Jaramillo Siddharth K. Shenoy Dorota Raclawska Nkechinyere A. Emezienna Vanessa L. Richardson Naoko Hara Anna Q. Harder James C. NeeDell Corinne E. Hennessy Hassan M. El-Batal Chelsea M. Magin Diane E. Grove Villalon Gregg Duncan Justin S. Hanes Jung Soo Suk David J. Thornton Fernando Holguin William J. Janssen William R. Thelin Christopher M. Evans
author_facet	Leslie E. Morgan Ana M. Jaramillo Siddharth K. Shenoy Dorota Raclawska Nkechinyere A. Emezienna Vanessa L. Richardson Naoko Hara Anna Q. Harder James C. NeeDell Corinne E. Hennessy Hassan M. El-Batal Chelsea M. Magin Diane E. Grove Villalon Gregg Duncan Justin S. Hanes Jung Soo Suk David J. Thornton Fernando Holguin William J. Janssen William R. Thelin Christopher M. Evans
author_sort	Leslie E. Morgan
title	Disulfide disruption reverses mucus dysfunction in allergic airway disease
title_short	Disulfide disruption reverses mucus dysfunction in allergic airway disease
title_full	Disulfide disruption reverses mucus dysfunction in allergic airway disease
title_fullStr	Disulfide disruption reverses mucus dysfunction in allergic airway disease
title_full_unstemmed	Disulfide disruption reverses mucus dysfunction in allergic airway disease
title_sort	disulfide disruption reverses mucus dysfunction in allergic airway disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fb68d67a4a24797aac17403bb6726b1
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Disulfide disruption reverses mucus dysfunction in allergic airway disease

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