Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus

The study of hereditary predisposition to multifactorial diseases is essential for diagnosis and selection of the optimal treatment. The study of polymorphisms of candidate genes whose products are involved in the pathogenesis of multifactorial diseases is of great clinical importance. Aim. The aim...

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Autores principales:	Dmitry Sergeevich Khodyrev, Aleksey Georgievna Nikitin, Aleksey Nikolaevich Brovkin, Elena Yur'evna Lavrikova, Nadezhda Olegovna Lebedeva, Olga Konstantinovna Vikulova, Minara Shamkhalovna Shamkhalova, Marina Vladimirovna Shestakova, Valery Vyacheslavovich Nosikov, Alexander Vyacheslavovich Averyanov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes adiponectin insulin resistance haplotype adipoq adipor1 adipor2 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/2fb8b248b88448398d42c478de0f8dba
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spelling	oai:doaj.org-article:2fb8b248b88448398d42c478de0f8dba2021-11-14T09:00:19ZAssociation of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus2072-03512072-037810.14341/DM201525-11https://doaj.org/article/2fb8b248b88448398d42c478de0f8dba2015-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6848https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The study of hereditary predisposition to multifactorial diseases is essential for diagnosis and selection of the optimal treatment. The study of polymorphisms of candidate genes whose products are involved in the pathogenesis of multifactorial diseases is of great clinical importance. Aim. The aim of this study was to investigate the association of rs2241766 and rs1501299 polymorphisms in the ADIPOQ gene, rs2275737 and rs2275738 polymorphisms in the ADIPOR1 gene and rs11061971 and rs16928751 polymorphisms in the ADIPOR2 gene with the development of type 2 diabetes mellitus (T2DM) in the Russian population. Materials and methods. The study included a group of 500 patients with T2DM diagnosed based on standard diagnostic criteria (T2DM+). The control group (T2DM-) was a random sample of 500 patients with no evidence of the disease and was matched to the T2DM+ group for gender, age and body mass index. The determination of alleles and genotypes was performed using real-time polymerase chain reaction with TaqMan probes. The X2 test and contingency tables were used to compare the distribution of allele and genotype frequencies. A p-value ofDmitry Sergeevich KhodyrevAleksey Georgievna NikitinAleksey Nikolaevich BrovkinElena Yur'evna LavrikovaNadezhda Olegovna LebedevaOlga Konstantinovna VikulovaMinara Shamkhalovna ShamkhalovaMarina Vladimirovna ShestakovaValery Vyacheslavovich NosikovAlexander Vyacheslavovich AveryanovEndocrinology Research Centrearticletype 2 diabetesadiponectininsulin resistancehaplotypeadipoqadipor1adipor2Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 2, Pp 5-11 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes adiponectin insulin resistance haplotype adipoq adipor1 adipor2 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes adiponectin insulin resistance haplotype adipoq adipor1 adipor2 Nutritional diseases. Deficiency diseases RC620-627 Dmitry Sergeevich Khodyrev Aleksey Georgievna Nikitin Aleksey Nikolaevich Brovkin Elena Yur'evna Lavrikova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Valery Vyacheslavovich Nosikov Alexander Vyacheslavovich Averyanov Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
description	The study of hereditary predisposition to multifactorial diseases is essential for diagnosis and selection of the optimal treatment. The study of polymorphisms of candidate genes whose products are involved in the pathogenesis of multifactorial diseases is of great clinical importance. Aim. The aim of this study was to investigate the association of rs2241766 and rs1501299 polymorphisms in the ADIPOQ gene, rs2275737 and rs2275738 polymorphisms in the ADIPOR1 gene and rs11061971 and rs16928751 polymorphisms in the ADIPOR2 gene with the development of type 2 diabetes mellitus (T2DM) in the Russian population. Materials and methods. The study included a group of 500 patients with T2DM diagnosed based on standard diagnostic criteria (T2DM+). The control group (T2DM-) was a random sample of 500 patients with no evidence of the disease and was matched to the T2DM+ group for gender, age and body mass index. The determination of alleles and genotypes was performed using real-time polymerase chain reaction with TaqMan probes. The X2 test and contingency tables were used to compare the distribution of allele and genotype frequencies. A p-value of
format	article
author	Dmitry Sergeevich Khodyrev Aleksey Georgievna Nikitin Aleksey Nikolaevich Brovkin Elena Yur'evna Lavrikova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Valery Vyacheslavovich Nosikov Alexander Vyacheslavovich Averyanov
author_facet	Dmitry Sergeevich Khodyrev Aleksey Georgievna Nikitin Aleksey Nikolaevich Brovkin Elena Yur'evna Lavrikova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Valery Vyacheslavovich Nosikov Alexander Vyacheslavovich Averyanov
author_sort	Dmitry Sergeevich Khodyrev
title	Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
title_short	Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
title_full	Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
title_fullStr	Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
title_full_unstemmed	Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus
title_sort	association of polymorphisms of the adipoq, adipor1 and adipor2 genes with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/2fb8b248b88448398d42c478de0f8dba
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Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus

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