Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysynaptic spines with normal morphology in a mouse mod...

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Autores principales:	Sam A. Booker, Aleksander P. F. Domanski, Owen R. Dando, Adam D. Jackson, John T. R. Isaac, Giles E. Hardingham, David J. A. Wyllie, Peter C. Kind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc102
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spelling	oai:doaj.org-article:2fbc40b23b8f4722ab1014116cebc1022021-12-02T15:35:59ZAltered dendritic spine function and integration in a mouse model of fragile X syndrome10.1038/s41467-019-11891-62041-1723https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc1022019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11891-6https://doaj.org/toc/2041-1723Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysynaptic spines with normal morphology in a mouse model of fragile X.Sam A. BookerAleksander P. F. DomanskiOwen R. DandoAdam D. JacksonJohn T. R. IsaacGiles E. HardinghamDavid J. A. WylliePeter C. KindNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sam A. Booker Aleksander P. F. Domanski Owen R. Dando Adam D. Jackson John T. R. Isaac Giles E. Hardingham David J. A. Wyllie Peter C. Kind Altered dendritic spine function and integration in a mouse model of fragile X syndrome
description	Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysynaptic spines with normal morphology in a mouse model of fragile X.
format	article
author	Sam A. Booker Aleksander P. F. Domanski Owen R. Dando Adam D. Jackson John T. R. Isaac Giles E. Hardingham David J. A. Wyllie Peter C. Kind
author_facet	Sam A. Booker Aleksander P. F. Domanski Owen R. Dando Adam D. Jackson John T. R. Isaac Giles E. Hardingham David J. A. Wyllie Peter C. Kind
author_sort	Sam A. Booker
title	Altered dendritic spine function and integration in a mouse model of fragile X syndrome
title_short	Altered dendritic spine function and integration in a mouse model of fragile X syndrome
title_full	Altered dendritic spine function and integration in a mouse model of fragile X syndrome
title_fullStr	Altered dendritic spine function and integration in a mouse model of fragile X syndrome
title_full_unstemmed	Altered dendritic spine function and integration in a mouse model of fragile X syndrome
title_sort	altered dendritic spine function and integration in a mouse model of fragile x syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc102
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Altered dendritic spine function and integration in a mouse model of fragile X syndrome

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