Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

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Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Two 24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues (<b>3</b>,<b>4</b>) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D<sub>3</sub> side-chain C24 position was achieved via Sharpless dihydroxylation, and...

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Auteurs principaux:	Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	human CYP24A1 synthesis vitamin D<sub>3</sub> metabolite 24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues Sharpless dihydroxylation Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/2fbcff291b1f4b25a493701f37d86ed8
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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