Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer

Kyung Dong Lee,1,* Young-Il Jeong,2,* Da Hye Kim,3,4 Gyun-Taek Lim,2 Ki-Choon Choi5 1Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea; 2Department of Polymer Engineering, Chonnam National University, Gwangju, South Korea; 3Faculty of Life and Environmental Science, S...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lee KD, Jeong YI, Kim DH, Lim GT, Choi KC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2fbf5ae2135549379c15da71de6d74b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2fbf5ae2135549379c15da71de6d74b3
record_format	dspace
spelling	oai:doaj.org-article:2fbf5ae2135549379c15da71de6d74b32021-12-02T02:28:08ZCisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer1176-91141178-2013https://doaj.org/article/2fbf5ae2135549379c15da71de6d74b32013-08-01T00:00:00Zhttp://www.dovepress.com/cisplatin-incorporated-nanoparticles-of-polyacrylic-acid-co-methyl-met-a13956https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kyung Dong Lee,1,* Young-Il Jeong,2,* Da Hye Kim,3,4 Gyun-Taek Lim,2 Ki-Choon Choi5 1Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea; 2Department of Polymer Engineering, Chonnam National University, Gwangju, South Korea; 3Faculty of Life and Environmental Science, Shimane University, Matsue, Japan; 4United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan; 5Grassland and Forages Division, National Institute of Animal Science, Rural Development Administration, Cheonan, South Korea *These authors contributed equally to this work Background: Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo. Methods: Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells. Results: Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model. Conclusion: We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system. Keywords: cisplatin, nanoparticle, poly(acrylic acid-co-methyl methacrylate), ion complexesLee KDJeong YIKim DHLim GTChoi KCDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2835-2845 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lee KD Jeong YI Kim DH Lim GT Choi KC Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
description	Kyung Dong Lee,1,* Young-Il Jeong,2,* Da Hye Kim,3,4 Gyun-Taek Lim,2 Ki-Choon Choi5 1Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea; 2Department of Polymer Engineering, Chonnam National University, Gwangju, South Korea; 3Faculty of Life and Environmental Science, Shimane University, Matsue, Japan; 4United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan; 5Grassland and Forages Division, National Institute of Animal Science, Rural Development Administration, Cheonan, South Korea *These authors contributed equally to this work Background: Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo. Methods: Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells. Results: Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model. Conclusion: We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system. Keywords: cisplatin, nanoparticle, poly(acrylic acid-co-methyl methacrylate), ion complexes
format	article
author	Lee KD Jeong YI Kim DH Lim GT Choi KC
author_facet	Lee KD Jeong YI Kim DH Lim GT Choi KC
author_sort	Lee KD
title	Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
title_short	Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
title_full	Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
title_fullStr	Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
title_full_unstemmed	Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
title_sort	cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2fbf5ae2135549379c15da71de6d74b3
work_keys_str_mv	AT leekd cisplatinincorporatednanoparticlesofpolyacrylicacidcomethylmethacrylatecopolymer AT jeongyi cisplatinincorporatednanoparticlesofpolyacrylicacidcomethylmethacrylatecopolymer AT kimdh cisplatinincorporatednanoparticlesofpolyacrylicacidcomethylmethacrylatecopolymer AT limgt cisplatinincorporatednanoparticlesofpolyacrylicacidcomethylmethacrylatecopolymer AT choikc cisplatinincorporatednanoparticlesofpolyacrylicacidcomethylmethacrylatecopolymer
_version_	1718402457824919552

Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer

Ejemplares similares