Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showing Smad3 and Smad4 bound to these motifs.

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Autores principales:	Pau Martin-Malpartida, Marta Batet, Zuzanna Kaczmarska, Regina Freier, Tiago Gomes, Eric Aragón, Yilong Zou, Qiong Wang, Qiaoran Xi, Lidia Ruiz, Angela Vea, José A. Márquez, Joan Massagué, Maria J. Macias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fc17c23ddc242eeb5acfe143eb35089
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spelling	oai:doaj.org-article:2fc17c23ddc242eeb5acfe143eb350892021-12-02T17:06:01ZStructural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors10.1038/s41467-017-02054-62041-1723https://doaj.org/article/2fc17c23ddc242eeb5acfe143eb350892017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02054-6https://doaj.org/toc/2041-1723Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showing Smad3 and Smad4 bound to these motifs.Pau Martin-MalpartidaMarta BatetZuzanna KaczmarskaRegina FreierTiago GomesEric AragónYilong ZouQiong WangQiaoran XiLidia RuizAngela VeaJosé A. MárquezJoan MassaguéMaria J. MaciasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pau Martin-Malpartida Marta Batet Zuzanna Kaczmarska Regina Freier Tiago Gomes Eric Aragón Yilong Zou Qiong Wang Qiaoran Xi Lidia Ruiz Angela Vea José A. Márquez Joan Massagué Maria J. Macias Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
description	Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showing Smad3 and Smad4 bound to these motifs.
format	article
author	Pau Martin-Malpartida Marta Batet Zuzanna Kaczmarska Regina Freier Tiago Gomes Eric Aragón Yilong Zou Qiong Wang Qiaoran Xi Lidia Ruiz Angela Vea José A. Márquez Joan Massagué Maria J. Macias
author_facet	Pau Martin-Malpartida Marta Batet Zuzanna Kaczmarska Regina Freier Tiago Gomes Eric Aragón Yilong Zou Qiong Wang Qiaoran Xi Lidia Ruiz Angela Vea José A. Márquez Joan Massagué Maria J. Macias
author_sort	Pau Martin-Malpartida
title	Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
title_short	Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
title_full	Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
title_fullStr	Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
title_full_unstemmed	Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
title_sort	structural basis for genome wide recognition of 5-bp gc motifs by smad transcription factors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2fc17c23ddc242eeb5acfe143eb35089
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Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

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