The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin.

Viperin, an antiviral protein, has been shown to contain a CX(3)CX(2)C motif, which is conserved in the radical S-adenosyl-methionine (SAM) enzyme family. A triple mutant which replaces these three cysteines with alanines has been shown to have severe deficiency in antiviral activity. Since the crys...

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Autores principales: Shubhasis Haldar, Simantasarani Paul, Nidhi Joshi, Anindya Dasgupta, Krishnananda Chattopadhyay
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/2fc1e933accd4621b36c3839bd4a3813
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