Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.

In humans, chronic inflammation, severe injury, infection and disease can result in changes in steroid hormone titers and delayed onset of puberty; however the pathway by which this occurs remains largely unknown. Similarly, in insects injury to specific tissues can result in a global developmental...

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Autores principales:	Jennifer F Hackney, Omid Zolali-Meybodi, Peter Cherbas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fc391e5882740289ffcb49320426330
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spelling	oai:doaj.org-article:2fc391e5882740289ffcb493204263302021-11-18T08:08:57ZTissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.1932-620310.1371/journal.pone.0049105https://doaj.org/article/2fc391e5882740289ffcb493204263302012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166607/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In humans, chronic inflammation, severe injury, infection and disease can result in changes in steroid hormone titers and delayed onset of puberty; however the pathway by which this occurs remains largely unknown. Similarly, in insects injury to specific tissues can result in a global developmental delay (e.g. prolonged larval/pupal stages) often associated with decreased levels of ecdysone - a steroid hormone that regulates developmental transitions in insects. We use Drosophila melanogaster as a model to examine the pathway by which tissue injury disrupts developmental progression. Imaginal disc damage inflicted early in larval development triggers developmental delays while the effects are minimized in older larvae. We find that the switch in injury response (e.g. delay/no delay) is coincident with the mid-3rd instar transition - a developmental time-point that is characterized by widespread changes in gene expression and marks the initial steps of metamorphosis. Finally, we show that developmental delays induced by tissue damage are associated with decreased expression of genes involved in ecdysteroid synthesis and signaling.Jennifer F HackneyOmid Zolali-MeybodiPeter CherbasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49105 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer F Hackney Omid Zolali-Meybodi Peter Cherbas Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
description	In humans, chronic inflammation, severe injury, infection and disease can result in changes in steroid hormone titers and delayed onset of puberty; however the pathway by which this occurs remains largely unknown. Similarly, in insects injury to specific tissues can result in a global developmental delay (e.g. prolonged larval/pupal stages) often associated with decreased levels of ecdysone - a steroid hormone that regulates developmental transitions in insects. We use Drosophila melanogaster as a model to examine the pathway by which tissue injury disrupts developmental progression. Imaginal disc damage inflicted early in larval development triggers developmental delays while the effects are minimized in older larvae. We find that the switch in injury response (e.g. delay/no delay) is coincident with the mid-3rd instar transition - a developmental time-point that is characterized by widespread changes in gene expression and marks the initial steps of metamorphosis. Finally, we show that developmental delays induced by tissue damage are associated with decreased expression of genes involved in ecdysteroid synthesis and signaling.
format	article
author	Jennifer F Hackney Omid Zolali-Meybodi Peter Cherbas
author_facet	Jennifer F Hackney Omid Zolali-Meybodi Peter Cherbas
author_sort	Jennifer F Hackney
title	Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
title_short	Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
title_full	Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
title_fullStr	Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
title_full_unstemmed	Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.
title_sort	tissue damage disrupts developmental progression and ecdysteroid biosynthesis in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2fc391e5882740289ffcb49320426330
work_keys_str_mv	AT jenniferfhackney tissuedamagedisruptsdevelopmentalprogressionandecdysteroidbiosynthesisindrosophila AT omidzolalimeybodi tissuedamagedisruptsdevelopmentalprogressionandecdysteroidbiosynthesisindrosophila AT petercherbas tissuedamagedisruptsdevelopmentalprogressionandecdysteroidbiosynthesisindrosophila
_version_	1718422158632288256

Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila.

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