Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome
Abstract Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapi...
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Nature Portfolio
2019
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oai:doaj.org-article:2fc63d568e3a479094d0d53486674d382021-12-02T15:08:07ZRetinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome10.1038/s41598-019-44647-92045-2322https://doaj.org/article/2fc63d568e3a479094d0d53486674d382019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44647-9https://doaj.org/toc/2045-2322Abstract Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapid and noninvasive assessment of systemic microvascularization, which is potentially involved in the occurrence of ICA-induced AKI. Between October 2016 and March 2017, 452 ACS patients were admitted to our cardiac intensive care unit. OCT-A was performed within 48 h after the ICA injection. Patients with a history of retinal disease were excluded. The patients included were divided into two groups depending on whether or not AKI occurred after injection of ICA, according to KDIGO criteria. Of the 216 patients included, 21 (10%) presented AKI. AKI was significantly associated with age, Mehran score, GRACE score, and NT-proBNP. AKI patients had significantly lower retinal vascular density (RVD)) and had more frequent low RVD (81% vs 45%, P = 0.002). Adding low RVD to the Mehran score and the NT-proBNP, or to the GRACE score and the NT-proBNP, significantly improved their predictive values, suggesting that systemic microvascular involvement remains incompletely addressed by either standard risk scores or factors known to be associated with ICA-induced AKI.Guillaume AlanCharles GuenanciaLouis ArnouldArthur AzemarStéphane PitoisMaud MazaFlorence BichatMarianne ZellerPierre-Henri GabrielleAlain Marie BronCatherine Creuzot-GarcherYves CottinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
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Medicine R Science Q Guillaume Alan Charles Guenancia Louis Arnould Arthur Azemar Stéphane Pitois Maud Maza Florence Bichat Marianne Zeller Pierre-Henri Gabrielle Alain Marie Bron Catherine Creuzot-Garcher Yves Cottin Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| description |
Abstract Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapid and noninvasive assessment of systemic microvascularization, which is potentially involved in the occurrence of ICA-induced AKI. Between October 2016 and March 2017, 452 ACS patients were admitted to our cardiac intensive care unit. OCT-A was performed within 48 h after the ICA injection. Patients with a history of retinal disease were excluded. The patients included were divided into two groups depending on whether or not AKI occurred after injection of ICA, according to KDIGO criteria. Of the 216 patients included, 21 (10%) presented AKI. AKI was significantly associated with age, Mehran score, GRACE score, and NT-proBNP. AKI patients had significantly lower retinal vascular density (RVD)) and had more frequent low RVD (81% vs 45%, P = 0.002). Adding low RVD to the Mehran score and the NT-proBNP, or to the GRACE score and the NT-proBNP, significantly improved their predictive values, suggesting that systemic microvascular involvement remains incompletely addressed by either standard risk scores or factors known to be associated with ICA-induced AKI. |
| format |
article |
| author |
Guillaume Alan Charles Guenancia Louis Arnould Arthur Azemar Stéphane Pitois Maud Maza Florence Bichat Marianne Zeller Pierre-Henri Gabrielle Alain Marie Bron Catherine Creuzot-Garcher Yves Cottin |
| author_facet |
Guillaume Alan Charles Guenancia Louis Arnould Arthur Azemar Stéphane Pitois Maud Maza Florence Bichat Marianne Zeller Pierre-Henri Gabrielle Alain Marie Bron Catherine Creuzot-Garcher Yves Cottin |
| author_sort |
Guillaume Alan |
| title |
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| title_short |
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| title_full |
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| title_fullStr |
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| title_full_unstemmed |
Retinal Vascular Density as A Novel Biomarker of Acute Renal Injury after Acute Coronary Syndrome |
| title_sort |
retinal vascular density as a novel biomarker of acute renal injury after acute coronary syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2fc63d568e3a479094d0d53486674d38 |
| work_keys_str_mv |
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