Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and als...

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Autores principales:	Victor Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Eve Janelle, Nathalie Vernoux, Marie-Ève Tremblay, Tobias Fuehrmann, Molly S. Shoichet, Steve Lacroix
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fc70e1ee997470e9a54f3634a92fb6e
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spelling	oai:doaj.org-article:2fc70e1ee997470e9a54f3634a92fb6e2021-12-02T16:58:27ZMicroglia are an essential component of the neuroprotective scar that forms after spinal cord injury10.1038/s41467-019-08446-02041-1723https://doaj.org/article/2fc70e1ee997470e9a54f3634a92fb6e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08446-0https://doaj.org/toc/2041-1723The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and also that inhibiting microglia activation impairs recovery in the early stages after spinal cord injury.Victor Bellver-LandeteFloriane BretheauBenoit MailhotNicolas VallièresMartine LessardMarie-Eve JanelleNathalie VernouxMarie-Ève TremblayTobias FuehrmannMolly S. ShoichetSteve LacroixNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victor Bellver-Landete Floriane Bretheau Benoit Mailhot Nicolas Vallières Martine Lessard Marie-Eve Janelle Nathalie Vernoux Marie-Ève Tremblay Tobias Fuehrmann Molly S. Shoichet Steve Lacroix Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
description	The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and also that inhibiting microglia activation impairs recovery in the early stages after spinal cord injury.
format	article
author	Victor Bellver-Landete Floriane Bretheau Benoit Mailhot Nicolas Vallières Martine Lessard Marie-Eve Janelle Nathalie Vernoux Marie-Ève Tremblay Tobias Fuehrmann Molly S. Shoichet Steve Lacroix
author_facet	Victor Bellver-Landete Floriane Bretheau Benoit Mailhot Nicolas Vallières Martine Lessard Marie-Eve Janelle Nathalie Vernoux Marie-Ève Tremblay Tobias Fuehrmann Molly S. Shoichet Steve Lacroix
author_sort	Victor Bellver-Landete
title	Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
title_short	Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
title_full	Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
title_fullStr	Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
title_full_unstemmed	Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
title_sort	microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2fc70e1ee997470e9a54f3634a92fb6e
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Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

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