A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients

David KadingSpecialty Eyecare Group, Kirkland, WA, USAObjective: To evaluate the safety of Systane® Ultra Lubricant Eye Drops (test solution) in contact lens wearers. A currently marketed contact lens rewetting drop was the control solution.Participants: This investigator- and patient-ma...

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Autor principal: David Kading
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Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/2fc75a6310dc4d989c20433a5e2c73db
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spelling oai:doaj.org-article:2fc75a6310dc4d989c20433a5e2c73db2021-12-02T02:06:55ZA two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients1177-54671177-5483https://doaj.org/article/2fc75a6310dc4d989c20433a5e2c73db2010-01-01T00:00:00Zhttp://www.dovepress.com/a-two-week-clinical-evaluation-of-the-safety-of-systanereg-ultra-in-co-a3890https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483David KadingSpecialty Eyecare Group, Kirkland, WA, USAObjective: To evaluate the safety of Systane® Ultra Lubricant Eye Drops (test solution) in contact lens wearers. A currently marketed contact lens rewetting drop was the control solution.Participants: This investigator- and patient-masked, single-site, randomized, and prospective study involved 45 successful contact lens wearers.Methods: Eligible subjects’ baseline biomicroscopy findings, visual acuity, and corneal staining score were recorded. Subjects received either the test or control solution with masked labeling. Subjects were instructed to instill their assigned solution in both eyes: 15 minutes prior to lens insertion, at least one drop during lens wear and another drop immediately following lens removal. After 14 days, biomicroscopy results, visual acuity, and corneal staining score were recorded.Results: No adverse events were documented for either the test or the control solution. For subjects using Systane® Ultra, no statistically significant change was detected in visual acuity (= 0.7667) or corneal staining score (P = 1.000). For subjects using the control solution, the change in visual acuity (P = 0.0011, mean difference = 1.70 ± 3.22 standard deviation) was not clinically relevant and there was no significant change in corneal staining score (P = 0.5413).Conclusions: This clinical study provided evidence of safety and compatibility of Systane® Ultra Lubricant Eye Drops in contact lens wearers.Keywords: lubricant eye drop, contact lens, safety, dry eye David KadingDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 27-32 (2010)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
David Kading
A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
description David KadingSpecialty Eyecare Group, Kirkland, WA, USAObjective: To evaluate the safety of Systane® Ultra Lubricant Eye Drops (test solution) in contact lens wearers. A currently marketed contact lens rewetting drop was the control solution.Participants: This investigator- and patient-masked, single-site, randomized, and prospective study involved 45 successful contact lens wearers.Methods: Eligible subjects’ baseline biomicroscopy findings, visual acuity, and corneal staining score were recorded. Subjects received either the test or control solution with masked labeling. Subjects were instructed to instill their assigned solution in both eyes: 15 minutes prior to lens insertion, at least one drop during lens wear and another drop immediately following lens removal. After 14 days, biomicroscopy results, visual acuity, and corneal staining score were recorded.Results: No adverse events were documented for either the test or the control solution. For subjects using Systane® Ultra, no statistically significant change was detected in visual acuity (= 0.7667) or corneal staining score (P = 1.000). For subjects using the control solution, the change in visual acuity (P = 0.0011, mean difference = 1.70 ± 3.22 standard deviation) was not clinically relevant and there was no significant change in corneal staining score (P = 0.5413).Conclusions: This clinical study provided evidence of safety and compatibility of Systane® Ultra Lubricant Eye Drops in contact lens wearers.Keywords: lubricant eye drop, contact lens, safety, dry eye
format article
author David Kading
author_facet David Kading
author_sort David Kading
title A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
title_short A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
title_full A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
title_fullStr A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
title_full_unstemmed A two-week clinical evaluation of the safety of Systane® Ultra in contact lens-wearing patients
title_sort two-week clinical evaluation of the safety of systane® ultra in contact lens-wearing patients
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/2fc75a6310dc4d989c20433a5e2c73db
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