Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy

Metabolic reprogramming is one of the emerging hallmarks of cancer and is driven by both the oncogenic mutations and challenging microenvironment. To satisfy the demands of energy and biomass for rapid proliferation, the metabolism of various nutrients in tumor cells undergoes important changes, amo...

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Autores principales:	Limeng Cai, Minfeng Ying, Hao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tumor micoenvironment metabolic reprogramming microenvironment factor cancer therapy lipid metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2fc94651da194b219dc127c57777cf16
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spelling	oai:doaj.org-article:2fc94651da194b219dc127c57777cf162021-11-30T12:24:07ZMicroenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy2234-943X10.3389/fonc.2021.777273https://doaj.org/article/2fc94651da194b219dc127c57777cf162021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.777273/fullhttps://doaj.org/toc/2234-943XMetabolic reprogramming is one of the emerging hallmarks of cancer and is driven by both the oncogenic mutations and challenging microenvironment. To satisfy the demands of energy and biomass for rapid proliferation, the metabolism of various nutrients in tumor cells undergoes important changes, among which the aberrant lipid metabolism has gained increasing attention in facilitating tumor development and metastasis in the past few years. Obstacles emerged in the aspect of application of targeting lipid metabolism for tumor therapy, due to lacking of comprehensive understanding on its regulating mechanism. Tumor cells closely interact with stromal niche, which highly contributes to metabolic rewiring of critical nutrients in cancer cells. This fact makes the impact of microenvironment on tumor lipid metabolism a topic of renewed interest. Abundant evidence has shown that many factors existing in the tumor microenvironment can rewire multiple signaling pathways and proteins involved in lipid metabolic pathways of cancer cells. Hence in this review, we summarized the recent progress on the understanding of microenvironmental factors regulating tumor lipid metabolism, and discuss the potential of modulating lipid metabolism as an anticancer approach.Limeng CaiMinfeng YingHao WuFrontiers Media S.A.articletumor micoenvironmentmetabolic reprogrammingmicroenvironment factorcancer therapylipid metabolismNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor micoenvironment metabolic reprogramming microenvironment factor cancer therapy lipid metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor micoenvironment metabolic reprogramming microenvironment factor cancer therapy lipid metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Limeng Cai Minfeng Ying Hao Wu Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
description	Metabolic reprogramming is one of the emerging hallmarks of cancer and is driven by both the oncogenic mutations and challenging microenvironment. To satisfy the demands of energy and biomass for rapid proliferation, the metabolism of various nutrients in tumor cells undergoes important changes, among which the aberrant lipid metabolism has gained increasing attention in facilitating tumor development and metastasis in the past few years. Obstacles emerged in the aspect of application of targeting lipid metabolism for tumor therapy, due to lacking of comprehensive understanding on its regulating mechanism. Tumor cells closely interact with stromal niche, which highly contributes to metabolic rewiring of critical nutrients in cancer cells. This fact makes the impact of microenvironment on tumor lipid metabolism a topic of renewed interest. Abundant evidence has shown that many factors existing in the tumor microenvironment can rewire multiple signaling pathways and proteins involved in lipid metabolic pathways of cancer cells. Hence in this review, we summarized the recent progress on the understanding of microenvironmental factors regulating tumor lipid metabolism, and discuss the potential of modulating lipid metabolism as an anticancer approach.
format	article
author	Limeng Cai Minfeng Ying Hao Wu
author_facet	Limeng Cai Minfeng Ying Hao Wu
author_sort	Limeng Cai
title	Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
title_short	Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
title_full	Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
title_fullStr	Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
title_full_unstemmed	Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy
title_sort	microenvironmental factors modulating tumor lipid metabolism: paving the way to better antitumoral therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2fc94651da194b219dc127c57777cf16
work_keys_str_mv	AT limengcai microenvironmentalfactorsmodulatingtumorlipidmetabolismpavingthewaytobetterantitumoraltherapy AT minfengying microenvironmentalfactorsmodulatingtumorlipidmetabolismpavingthewaytobetterantitumoraltherapy AT haowu microenvironmentalfactorsmodulatingtumorlipidmetabolismpavingthewaytobetterantitumoraltherapy
_version_	1718406612813611008

Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy

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