Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics

Microfluidics is emerging as a promising tool to control physicochemical properties of nanoparticles and to accelerate clinical translation. Indeed, microfluidic-based techniques offer more advantages in nanomedicine over batch processes, allowing fine-tuning of process parameters. In particular, th...

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Autores principales:	Alessio Smeraldo, Alfonso Maria Ponsiglione, Paolo Antonio Netti, Enza Torino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microfluidics ionotropic gelation hydrogel Hydrodenticity multimodal imaging Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2fcac7cea5554eada68ab5dc8ee9e92f
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spelling	oai:doaj.org-article:2fcac7cea5554eada68ab5dc8ee9e92f2021-11-25T16:48:55ZTuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics10.3390/biomedicines91115512227-9059https://doaj.org/article/2fcac7cea5554eada68ab5dc8ee9e92f2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1551https://doaj.org/toc/2227-9059Microfluidics is emerging as a promising tool to control physicochemical properties of nanoparticles and to accelerate clinical translation. Indeed, microfluidic-based techniques offer more advantages in nanomedicine over batch processes, allowing fine-tuning of process parameters. In particular, the use of microfluidics to produce nanoparticles has paved the way for the development of nano-scaled structures for improved detection and treatment of several diseases. Here, ionotropic gelation is implemented in a custom-designed microfluidic chip to produce different nanoarchitectures based on chitosan-hyaluronic acid polymers. The selected biomaterials provide biocompatibility, biodegradability and non-toxic properties to the formulation, making it promising for nanomedicine applications. Furthermore, results show that morphological structures can be tuned through microfluidics by controlling the flow rates. Aside from the nanostructures, the ability to encapsulate gadolinium contrast agent for magnetic resonance imaging and a dye for optical imaging is demonstrated. In conclusion, the polymer nanoparticles here designed revealed the dual capability of enhancing the relaxometric properties of gadolinium by attaining Hydrodenticity and serving as a promising nanocarrier for multimodal imaging applications.Alessio SmeraldoAlfonso Maria PonsiglionePaolo Antonio NettiEnza TorinoMDPI AGarticlemicrofluidicsionotropic gelationhydrogelHydrodenticitymultimodal imagingBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1551, p 1551 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microfluidics ionotropic gelation hydrogel Hydrodenticity multimodal imaging Biology (General) QH301-705.5
spellingShingle	microfluidics ionotropic gelation hydrogel Hydrodenticity multimodal imaging Biology (General) QH301-705.5 Alessio Smeraldo Alfonso Maria Ponsiglione Paolo Antonio Netti Enza Torino Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
description	Microfluidics is emerging as a promising tool to control physicochemical properties of nanoparticles and to accelerate clinical translation. Indeed, microfluidic-based techniques offer more advantages in nanomedicine over batch processes, allowing fine-tuning of process parameters. In particular, the use of microfluidics to produce nanoparticles has paved the way for the development of nano-scaled structures for improved detection and treatment of several diseases. Here, ionotropic gelation is implemented in a custom-designed microfluidic chip to produce different nanoarchitectures based on chitosan-hyaluronic acid polymers. The selected biomaterials provide biocompatibility, biodegradability and non-toxic properties to the formulation, making it promising for nanomedicine applications. Furthermore, results show that morphological structures can be tuned through microfluidics by controlling the flow rates. Aside from the nanostructures, the ability to encapsulate gadolinium contrast agent for magnetic resonance imaging and a dye for optical imaging is demonstrated. In conclusion, the polymer nanoparticles here designed revealed the dual capability of enhancing the relaxometric properties of gadolinium by attaining Hydrodenticity and serving as a promising nanocarrier for multimodal imaging applications.
format	article
author	Alessio Smeraldo Alfonso Maria Ponsiglione Paolo Antonio Netti Enza Torino
author_facet	Alessio Smeraldo Alfonso Maria Ponsiglione Paolo Antonio Netti Enza Torino
author_sort	Alessio Smeraldo
title	Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
title_short	Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
title_full	Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
title_fullStr	Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
title_full_unstemmed	Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics
title_sort	tuning of hydrogel architectures by ionotropic gelation in microfluidics: beyond batch processing to multimodal diagnostics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2fcac7cea5554eada68ab5dc8ee9e92f
work_keys_str_mv	AT alessiosmeraldo tuningofhydrogelarchitecturesbyionotropicgelationinmicrofluidicsbeyondbatchprocessingtomultimodaldiagnostics AT alfonsomariaponsiglione tuningofhydrogelarchitecturesbyionotropicgelationinmicrofluidicsbeyondbatchprocessingtomultimodaldiagnostics AT paoloantonionetti tuningofhydrogelarchitecturesbyionotropicgelationinmicrofluidicsbeyondbatchprocessingtomultimodaldiagnostics AT enzatorino tuningofhydrogelarchitecturesbyionotropicgelationinmicrofluidicsbeyondbatchprocessingtomultimodaldiagnostics
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Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics

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