Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer

ABSTRACT The oral periodontopathic bacterium Fusobacterium nucleatum has been repeatedly associated with colorectal tumors. Molecular analysis has identified specific virulence factors that promote tumorigenesis in the colon. However, other oral community members, such as members of the Porphyromona...

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Autores principales:	Kaitlin J. Flynn, Nielson T. Baxter, Patrick D. Schloss
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	colorectal cancer microbial ecology microbiome oral microbiology pathogenesis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2fcbb14163a44e4085993d0af4ae0167
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spelling	oai:doaj.org-article:2fcbb14163a44e4085993d0af4ae01672021-11-15T15:21:18ZMetabolic and Community Synergy of Oral Bacteria in Colorectal Cancer10.1128/mSphere.00102-162379-5042https://doaj.org/article/2fcbb14163a44e4085993d0af4ae01672016-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00102-16https://doaj.org/toc/2379-5042ABSTRACT The oral periodontopathic bacterium Fusobacterium nucleatum has been repeatedly associated with colorectal tumors. Molecular analysis has identified specific virulence factors that promote tumorigenesis in the colon. However, other oral community members, such as members of the Porphyromonas spp., are also found with F. nucleatum on colonic tumors, and thus, narrow studies of individual pathogens do not take community-wide virulence properties into account. A broader view of oral bacterial physiology and pathogenesis identifies two factors that could promote colonization and persistence of oral bacterial communities in the colon. The polymicrobial nature of oral biofilms and the asaccharolytic metabolism of many of these species make them well suited to life in the microenvironment of colonic lesions. Consideration of these two factors offers a novel perspective on the role of oral microbiota in the initiation, development, and treatment of colorectal cancer.Kaitlin J. FlynnNielson T. BaxterPatrick D. SchlossAmerican Society for Microbiologyarticlecolorectal cancermicrobial ecologymicrobiomeoral microbiologypathogenesisMicrobiologyQR1-502ENmSphere, Vol 1, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer microbial ecology microbiome oral microbiology pathogenesis Microbiology QR1-502
spellingShingle	colorectal cancer microbial ecology microbiome oral microbiology pathogenesis Microbiology QR1-502 Kaitlin J. Flynn Nielson T. Baxter Patrick D. Schloss Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
description	ABSTRACT The oral periodontopathic bacterium Fusobacterium nucleatum has been repeatedly associated with colorectal tumors. Molecular analysis has identified specific virulence factors that promote tumorigenesis in the colon. However, other oral community members, such as members of the Porphyromonas spp., are also found with F. nucleatum on colonic tumors, and thus, narrow studies of individual pathogens do not take community-wide virulence properties into account. A broader view of oral bacterial physiology and pathogenesis identifies two factors that could promote colonization and persistence of oral bacterial communities in the colon. The polymicrobial nature of oral biofilms and the asaccharolytic metabolism of many of these species make them well suited to life in the microenvironment of colonic lesions. Consideration of these two factors offers a novel perspective on the role of oral microbiota in the initiation, development, and treatment of colorectal cancer.
format	article
author	Kaitlin J. Flynn Nielson T. Baxter Patrick D. Schloss
author_facet	Kaitlin J. Flynn Nielson T. Baxter Patrick D. Schloss
author_sort	Kaitlin J. Flynn
title	Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
title_short	Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
title_full	Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
title_fullStr	Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
title_full_unstemmed	Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
title_sort	metabolic and community synergy of oral bacteria in colorectal cancer
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/2fcbb14163a44e4085993d0af4ae0167
work_keys_str_mv	AT kaitlinjflynn metabolicandcommunitysynergyoforalbacteriaincolorectalcancer AT nielsontbaxter metabolicandcommunitysynergyoforalbacteriaincolorectalcancer AT patrickdschloss metabolicandcommunitysynergyoforalbacteriaincolorectalcancer
_version_	1718428119603347456

Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer

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