A quantized mechanism for activation of pannexin channels

Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance state and fine tunes its activity.

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Autores principales:	Yu-Hsin Chiu, Xueyao Jin, Christopher B. Medina, Susan A. Leonhardt, Volker Kiessling, Brad C. Bennett, Shaofang Shu, Lukas K. Tamm, Mark Yeager, Kodi S. Ravichandran, Douglas A. Bayliss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fd253debe324fffb44a894dc4d37c5c
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spelling	oai:doaj.org-article:2fd253debe324fffb44a894dc4d37c5c2021-12-02T14:40:36ZA quantized mechanism for activation of pannexin channels10.1038/ncomms143242041-1723https://doaj.org/article/2fd253debe324fffb44a894dc4d37c5c2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14324https://doaj.org/toc/2041-1723Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance state and fine tunes its activity.Yu-Hsin ChiuXueyao JinChristopher B. MedinaSusan A. LeonhardtVolker KiesslingBrad C. BennettShaofang ShuLukas K. TammMark YeagerKodi S. RavichandranDouglas A. BaylissNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Hsin Chiu Xueyao Jin Christopher B. Medina Susan A. Leonhardt Volker Kiessling Brad C. Bennett Shaofang Shu Lukas K. Tamm Mark Yeager Kodi S. Ravichandran Douglas A. Bayliss A quantized mechanism for activation of pannexin channels
description	Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance state and fine tunes its activity.
format	article
author	Yu-Hsin Chiu Xueyao Jin Christopher B. Medina Susan A. Leonhardt Volker Kiessling Brad C. Bennett Shaofang Shu Lukas K. Tamm Mark Yeager Kodi S. Ravichandran Douglas A. Bayliss
author_facet	Yu-Hsin Chiu Xueyao Jin Christopher B. Medina Susan A. Leonhardt Volker Kiessling Brad C. Bennett Shaofang Shu Lukas K. Tamm Mark Yeager Kodi S. Ravichandran Douglas A. Bayliss
author_sort	Yu-Hsin Chiu
title	A quantized mechanism for activation of pannexin channels
title_short	A quantized mechanism for activation of pannexin channels
title_full	A quantized mechanism for activation of pannexin channels
title_fullStr	A quantized mechanism for activation of pannexin channels
title_full_unstemmed	A quantized mechanism for activation of pannexin channels
title_sort	quantized mechanism for activation of pannexin channels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2fd253debe324fffb44a894dc4d37c5c
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A quantized mechanism for activation of pannexin channels

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